公开(公告)号：EP2847632A1

公开(公告)日：2015-03-18

申请号：EP13722347.5

申请日：2013-05-03

申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  UNIVERSITE RENE DESCARTES - PARIS V

发明人： GUILLON, Marc ,  LAUTERBACH, Marcel ,  EMILIANI, Valentina

IPC分类号： G02B21/00 ,  G02B27/58

CPC分类号： G02B21/0032 ,  G01N21/6402 ,  G01N21/645 ,  G01N2021/6463 ,  G02B21/0056 ,  G02B21/0076

摘要： A microscope (1) for high spatial resolution imaging a structure of interest in a sample (2) comprising a substance having a first state with first spectral properties and a second state with second spectral properties, the microscope comprising: an objective-lens assembly (3), a wave front modulating optical device (10) adapted to spatially vary an intensity of a transfer light beam (5b), a probe detector (15) arranged to detect an optical measurement signal from a portion of the substance in the second state and placed in an area of the transfer light beam (5b) with an intensity adapted not to transfer the substance between the first and second states said microscope (1) comprising a phase contrast microscopy system which includes an intensity detector (26) arranged to detect an intensity of an illuminating light beam (17) after said illuminating light beam (17) has passed through the sample (2), the objective-lens assembly (3) and the wave front modulating optical device (10).

公开(公告)号：EP3974792A1

公开(公告)日：2022-03-30

申请号：EP20306121.3

申请日：2020-09-29

申请人： Université de Paris ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut National de la Santé et de la Recherche Médicale (INSERM) ,  Sorbonne Université

发明人： GUILLON, Marc ,  TESSIER, Gilles ,  WU, Tengfei ,  BERTO, Pascal

IPC分类号： G01J9/00

摘要： A method for determining wavefront shapes of N angular channels C L of different propagation directions P L , said propagation directions P L being determined by a mean propagation direction vector u L ⇀ , from a single signal image acquisition I(x,y) of a multi-angular signal light beam containing said angular channels, each angular channel Ci being separated from other angular channels Cj by an angular separation Δα ij defined by Δ α ij = arccos u ι ⇀ u J ⇀ , where "." stands for the inner product between u ι ⇀ and u J ⇀ .