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1.发明授权HMGB1 AND ANTI-HMGB1 ANTIBODIES FOR THE PROGNOSTIC OF NEUROLOGICAL DISORDERS 有权HMGB1和抗HMGB1抗体的预测神经系统疾病
公开(公告)号：EP2545380B1
公开(公告)日：2014-12-10
申请号：EP11710151.9
申请日：2011-03-10
申请人： Institut Pasteur
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/6896 , A61B5/0042 , A61B5/055 , A61B5/15 , A61B5/4029 , A61B5/4064 , A61B5/407 , A61B5/4082 , A61B5/4088 , A61B2010/0077 , G01N33/56988 , G01N33/6854 , G01N2333/16 , G01N2333/52 , G01N2333/522 , G01N2333/523 , G01N2800/28 , G01N2800/56
摘要： The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a HIV-infected subject, and the use of this method to monitor the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV. The invention also concerns a prognostic method of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a HIV-infected patient.
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2.发明公开MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE 有权监测和感染人类免疫缺陷病毒的抑制通过调节HIV-1复制和生活的HMGB1依赖性激活
公开(公告)号：EP2329266A1
公开(公告)日：2011-06-08
申请号：EP09782934.5
申请日：2009-09-11
申请人： Institut Pasteur
发明人： GOUGEON, Marie-Lise , SAIDI, Hela , MELKI, Maria-Thérèse , POIRIER-BEAUDOIN, Béatrice , SEFFER, Valérie
IPC分类号： G01N33/50
CPC分类号： G01N33/6875 , A61K31/00 , A61K31/704 , C12N2740/16011 , G01N33/56988 , G01N2333/16 , G01N2333/4703 , G01N2800/52
摘要： Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample.
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3.发明授权MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE 有权监测和感染人类免疫缺陷病毒的抑制通过调节HIV-1复制和生活的HMGB1依赖性激活
公开(公告)号：EP2329266B1
公开(公告)日：2016-03-30
申请号：EP09782934.5
申请日：2009-09-11
申请人： Institut Pasteur
发明人： GOUGEON, Marie-Lise , SAIDI, Hela , MELKI, Maria-Thérèse , POIRIER-BEAUDOIN, Béatrice , SEFFER, Valérie
IPC分类号： G01N33/50
CPC分类号： G01N33/6875 , A61K31/00 , A61K31/704 , C12N2740/16011 , G01N33/56988 , G01N2333/16 , G01N2333/4703 , G01N2800/52
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4.发明公开HMGB1 AND ANTI-HMGB1 ANTIBODIES FOR THE PROGNOSTIC OF NEUROLOGICAL DISORDERS 有权HMGB1和抗HMGB1抗体的预测神经系统疾病
公开(公告)号：EP2545380A2
公开(公告)日：2013-01-16
申请号：EP11710151.9
申请日：2011-03-10
申请人： Institut Pasteur
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/6896 , A61B5/0042 , A61B5/055 , A61B5/15 , A61B5/4029 , A61B5/4064 , A61B5/407 , A61B5/4082 , A61B5/4088 , A61B2010/0077 , G01N33/56988 , G01N33/6854 , G01N2333/16 , G01N2333/52 , G01N2333/522 , G01N2333/523 , G01N2800/28 , G01N2800/56
摘要： The invention relates to in vitro method for quantitating the antibodies specific for High mobility group box I (HMGB1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a HIV-infected subject, and the use of this method to monitor the human immunodeficiency virus (HIV) infection of a subject who is known to be infected with HIV. The invention also concerns a prognostic method of the state of progression of Acquired immune deficiency syndrome (AIDS) or the state of progression toward AIDS, in particular the state of progression or the state of progression toward neurological disorders associated with AIDS. Finally, the invention is also about method to determine the immune deficiency or level of immune activation of a HIV-infected patient.
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