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1.发明公开
公开(公告)号：EP2686019A1
公开(公告)日：2014-01-22
申请号：EP12710480.0
申请日：2012-03-16
申请人： Institut Pasteur , Centre National de la Recherche Scientifique (CNRS) , Université Paris Sud XI
IPC分类号： A61K47/48 , C07K14/705 , A61P31/18
CPC分类号： A61K47/48276 , A61K38/16 , A61K38/177 , A61K38/195 , A61K47/6425 , C07K14/70514 , C07K14/70539 , C07K17/02 , C07K2319/00
摘要： This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
摘要翻译： 本发明涉及一种共轭分子，其包含从在由左的手段，以及用于其制备方法的有机分子耦合到所述衍生自CD4受体的肽。 所述有机分子包含一个13个氨基酸的多肽阴离子。 这样的共轭分子可以用于抗病毒治疗中使用，即在AIDS的治疗。
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公开(公告)号：EP2054439A1
公开(公告)日：2009-05-06
申请号：EP07802491.6
申请日：2007-08-03
IPC分类号： C07K14/705 , A61K38/16
CPC分类号： C07K14/70514
摘要： The present invention relates to an activated peptide derived from the CD4 receptor, which is capable of coupling by covalent bonding to an organic molecule and thus makes it possible to generate multiple potentially antiviral derivatives. The present invention also relates to a conjugated molecule comprising the CD4-receptor-derived peptide and an organic molecule, preferably the GPR1 peptide or a polyanion. Such a conjugated molecule can in particular be used in antiviral treatments, in particular the treatment of AIDS. The invention also relates to the methods for preparing the activated peptide derived from the CD4 receptor and the conjugated molecule.
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3.发明公开CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO AN ANIONIC POLYPEPTIDE FOR THE TREATMENT OF AIDS 审中-公开包含CD4受体偶联于阴离子多肽治疗艾滋病的肽的共轭分子
公开(公告)号：EP3220957A1
公开(公告)日：2017-09-27
申请号：EP15784690.8
申请日：2015-10-23
申请人： Institut Pasteur , Commissariat à l'Énergie Atomique et aux Énergies Alternatives , Universite Paris-Sud , Université Grenoble Alpes , Centre National de la Recherche Scientifique (CNRS)
CPC分类号： A61K47/645 , A61K38/00 , C07K14/70514
摘要： This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Said organic molecule comprises a 5 to 21 amino acid anionic polypeptide. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
摘要翻译： 本发明涉及包含衍生自通过接头偶联到有机分子上的CD4受体的肽的共轭分子及其制备方法。 所述有机分子包含5至21个氨基酸的阴离子多肽。 这种结合分子可用于抗病毒治疗，即用于治疗艾滋病。
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4.发明公开CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO A POLYANION FOR THE TREATMENT OF AIDS 有权共轭分子与A复杂耦合CD4受体肽FOR AIDS的治疗
公开(公告)号：EP2249873A2
公开(公告)日：2010-11-17
申请号：EP09708799.3
申请日：2009-01-27
申请人： Institut Pasteur , Commissariat à l'Énergie Atomique et aux Énergies Alternatives , UNIVERSITE PARIS-SUD 11 , Centre National De La Recherche Scientifique CNRS
CPC分类号： A61K47/48276 , A61K38/00 , A61K38/14 , A61K38/16 , A61K38/1761 , A61K47/61 , A61K47/6425 , C07K14/70514
摘要： This invention relates to a conjugated molecule comprising a peptide derived from the CD4 receptor coupled to an organic molecule by means of a linker as well as a process for its preparation. Such a conjugated molecule can be used in antiviral treatment, namely in the treatment of AIDS.
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公开(公告)号：EP2054439B1
公开(公告)日：2011-06-01
申请号：EP07802491.6
申请日：2007-08-03
IPC分类号： C07K14/705 , A61K38/16
CPC分类号： C07K14/70514
摘要： The present invention relates to an activated peptide derived from the CD4 receptor, which is capable of coupling by covalent bonding to an organic molecule and thus makes it possible to generate multiple potentially antiviral derivatives. The present invention also relates to a conjugated molecule comprising the CD4-receptor-derived peptide and an organic molecule, preferably the GPR1 peptide or a polyanion. Such a conjugated molecule can in particular be used in antiviral treatments, in particular the treatment of AIDS. The invention also relates to the methods for preparing the activated peptide derived from the CD4 receptor and the conjugated molecule.
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6.发明授权
公开(公告)号：EP2686019B1
公开(公告)日：2017-03-01
申请号：EP12710480.0
申请日：2012-03-16
申请人： Institut Pasteur , Centre National de la Recherche Scientifique (C.N.R.S.) , Université Paris Sud XI
IPC分类号： A61K47/64 , C07K14/705 , A61P31/18
CPC分类号： A61K47/48276 , A61K38/16 , A61K38/177 , A61K38/195 , A61K47/6425 , C07K14/70514 , C07K14/70539 , C07K17/02 , C07K2319/00
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8.发明授权POLYPEPTIDES TARGETING GLYCOSYLATED MUC2 PROTEINS, METHODS OF SYNTHESIS, THEIR NUCLEIC ACIDS AND USES THEREOF 有权ON糖化蛋白MUC2多肽LOOKING，合成，及其核酸和方法及其用途
公开(公告)号：EP2753639B1
公开(公告)日：2017-03-01
申请号：EP12755887.2
申请日：2012-09-07
申请人： Institut Pasteur
IPC分类号： C07K14/195 , C07K14/335 , A61K38/16 , C12N1/15 , C12N1/21 , C12N5/10 , G01N33/68 , G01N33/58 , C07K14/315 , C07K7/08
CPC分类号： C07K14/335 , C07K7/08 , C07K14/195 , C07K14/315 , C07K2319/60 , C07K2319/61 , C12P21/02 , G01N33/6893
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9.发明公开STAPLED PEPTIDE INHIBITORS OF NEMO AS POTENTIAL ANTI-INFLAMMATORY AND ANTI-CANCER DRUGS 审中-公开NEMO作为潜在抗炎药和抗癌药的标准肽抑制剂
公开(公告)号：EP3184541A1
公开(公告)日：2017-06-28
申请号：EP15307137.8
申请日：2015-12-23
申请人： Institut Pasteur
CPC分类号： C07K14/4702 , C07K2319/03
摘要： The invention concerns stapled peptide inhibitors of NEMO which inhibit the Nuclear Factor κB (NF-κB) signaling pathway and are useful as medicine candidates, in particular as anti-inflammatory or anticancer drugs.
摘要翻译： 本发明涉及NEMO的钉合肽抑制剂，其抑制核因子κB（NF-κB）信号传导途径并且可用作药物候选物，特别是作为抗炎或抗癌药物。
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10.发明授权CONJUGATED MOLECULES COMPRISING A PEPTIDE DERIVED FROM THE CD4 RECEPTOR COUPLED TO A POLYANION FOR THE TREATMENT OF AIDS 有权共轭分子与A复杂耦合CD4受体肽FOR AIDS的治疗
公开(公告)号：EP2249873B1
公开(公告)日：2016-11-16
申请号：EP09708799.3
申请日：2009-01-27
申请人： Institut Pasteur , Commissariat à l'Énergie Atomique et aux Énergies Alternatives , UNIVERSITE PARIS-SUD 11 , Centre National de la Recherche Scientifique (C.N.R.S.)
CPC分类号： A61K47/48276 , A61K38/00 , A61K38/14 , A61K38/16 , A61K38/1761 , A61K47/61 , A61K47/6425 , C07K14/70514
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