公开(公告)号：EP2341908B1

公开(公告)日：2016-04-13

申请号：EP08875931.1

申请日：2008-09-26

申请人： Institut de Cancérologie de l'Ouest (I.C.O) ,  UNIVERSITE D'ANGERS

发明人： GAMELIN, Erick ,  BOISDRON-CELLE, Michèle ,  MOREL, Alain

IPC分类号： A61P35/00

CPC分类号： A61K31/513 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/39558 ,  A61K2300/00

公开(公告)号：EP2335074B1

公开(公告)日：2013-03-20

申请号：EP08875930.3

申请日：2008-09-26

申请人： Institut de Cancérologie de l'Ouest (I.C.O) ,  UNIVERSITE D'ANGERS

发明人： GAMELIN, Erick ,  BOISDRON-CELLE, Michèle ,  MOREL, Alain

IPC分类号： G01N33/574 ,  G01N33/94

CPC分类号： G01N33/94 ,  G01N33/57419 ,  G01N2800/52

公开(公告)号：EP4150082A1

公开(公告)日：2023-03-22

申请号：EP21725177.6

申请日：2021-05-12

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM ,  UNIVERSITE D'ANGERS ,  ICO (Institut de Cancérologie de l'Ouest)

发明人： BILLAUD, Amandine ,  CHEVALIER, Louise-Marie ,  MOREL, Alain

IPC分类号： C12N15/113 ,  C12Q1/6827

公开(公告)号：EP2341908A1

公开(公告)日：2011-07-13

申请号：EP08875931.1

申请日：2008-09-26

申请人： Centre Regional de Lutte Contre le Cancer D'Angers ,  UNIVERSITE D'ANGERS

发明人： GAMELIN, Erick ,  BOISDRON-CELLE, Michèle ,  MOREL, Alain

IPC分类号： A61K31/4745 ,  A61K31/513 ,  A61K31/519 ,  A61K39/395 ,  A61P39/00

CPC分类号： A61K31/513 ,  A61K31/4745 ,  A61K31/519 ,  A61K39/39558 ,  A61K2300/00

摘要： The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5 -FU dose administered by continuous infusion in patients treated by a FOLFIRI regimen or a similar regimen, based on the 5 -FU plasmatic concentration measured during the previous 5 -FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5 -FU dose administered in continuous infusion in each FOLFIRI or similar treatment cycle is optimized using the decision algorithm according to the invention.

公开(公告)号：EP2335074A1

公开(公告)日：2011-06-22

申请号：EP08875930.3

申请日：2008-09-26

申请人： Centre Regional de Lutte Contre le Cancer D'Angers ,  UNIVERSITE D'ANGERS

发明人： GAMELIN, Erick ,  BOISDRON-CELLE, Michèle ,  MOREL, Alain

IPC分类号： G01N33/574 ,  G01N33/94

CPC分类号： G01N33/94 ,  G01N33/57419 ,  G01N2800/52

摘要： The present invention belongs to the field of improved personalized medicine. More precisely, the present invention relates to a method for progressively optimizing the 5 -FU dose administered by continuous infusion in patients treated by a FOLFOX regimen or a similar regimen, based on the 5 -FU plasmatic concentration measured during the previous 5 -FU continuous infusion and on a herein described decision algorithm. The present invention also relates to a method for treating a cancer patient in which the 5 -FU dose administered in continuous infusion in each FOLFOX or similar treatment cycle is optimized using the decision algorithm according to the invention.