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公开(公告)号：EP1712643B1
公开(公告)日：2016-04-06
申请号：EP06290592.2
申请日：2006-04-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/142 , C12Q2600/158 , C12Q2600/16
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2.发明公开USE OF THE OLFACTOMEDIN-4 PROTEIN (OLFM4) IN COLORECTAL CANCER DIAGNOSIS 有权VERWENDUNG DES OLFACTOMEDIN-4-PROTEIN（OLFM4）BEI DER DIAGNOSE VON KOLOREKTALKARZINOM
公开(公告)号：EP2681330A1
公开(公告)日：2014-01-08
申请号：EP11719644.4
申请日：2011-03-02
IPC分类号： C12Q1/68
CPC分类号： G01N33/57488 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , A61K33/24 , A61K39/395 , A61K39/39558 , A61K45/06 , C12Q1/6886 , C12Q2600/118 , G01N33/57419 , G01N2001/284 , A61K2300/00
摘要： The present invention provides a method for diagnosing KRAS mutations in colorectal cancers by measuring the level of OLFM4. In another aspect, the present invention relates a method of predicting the responds to a chemotherapeutic agent of a subject suffering from a colorectal cancer: according to the present invention, the by determining the OLFM4 levels. According to the present invention, the response can be predicted by determining the OLFM4 levels. This result in turn permits the design or the adaptation of a treatment of the said subject with the said chemotherapeutic agent.
摘要翻译： 本发明提供了一种通过测量OLFM4的水平来诊断结肠直肠癌中KRAS突变的方法。 在另一方面，本发明涉及预测患有结肠直肠癌患者的化学治疗剂的反应的方法：根据本发明，通过确定OLFM4水平。 根据本发明，可以通过确定OLFM4级别来预测响应。 该结果又允许用所述化学治疗剂对所述受试者的治疗的设计或适应。
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3.发明公开
公开(公告)号：EP4112060A1
公开(公告)日：2023-01-04
申请号：EP21183145.8
申请日：2021-07-01
申请人： Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) , Institut de Cancérologie de l'Ouest (I.C.O) , Universite de Nantes , Institut National de la Santé et de la Recherche Médicale (INSERM)
发明人： COLLIEC-JOUAULT, Sylvia , SINQUIN, Corinne , MUNOZ GARCIA, Javier , HEYMANN, Dominique , ZYKWINSKA, Agata
IPC分类号： A61K31/737 , A61P35/00
摘要： The invention provides low-molecular-weight non-sulfated or sulfated exopolysaccharide derivatives prepared from a marine native exopolysaccharide excreted by a mesophilic marine bacterium from a deep-sea hydrothermal environment (the HE800 strain, a Vibrio diabolicus species of the Vibrio genus), and relates to the use of such low-molecular-weight exopolysaccharide derivatives for the treatment of cancer.
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4.发明公开
公开(公告)号：EP3329937A1
公开(公告)日：2018-06-06
申请号：EP16002576.3
申请日：2016-12-05
申请人： OGD2 Pharma , Université de Nantes , Centre National de la Recherche Scientifique CNRS , Institut National de la Santé et de la Recherche Médicale (INSERM) , Institut de Cancérologie de l'Ouest (I.C.O)
发明人： BIRKLE, Stéphane , FLEURENCE, Julien , FARAJ, Sébastien , LE DOUSSAL, Jean-Marc , COCHONNEAU, Denis , TERME, Mickaël , ASSOULINE, Brigitte
IPC分类号： A61K39/395 , C07K16/30 , A61K39/00
CPC分类号： C07K16/3084 , A61K39/39558 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/73
摘要： The present disclosure relates to a composition for delivery of an anti-cancer agent into a cell, expressing the OAcGD2 ganglioside comprising:
(i) at least one anti-cancer agent, and
(ii) at least one antibody recognizing the OAcGD2 ganglioside, wherein the at least one antibody recognizing the OAcGD2 ganglioside enhances the uptake of the at least one anti-cancer agent by the tumor cell. The antibody is known and is named the 8B6 antibody. Several variants of the variable claimed, including consensus sequences. Experimental results are provided for a limited number of anti-cancer agents (topotecan, doxorubicin, temozolomide).
Combined therapy with said agents show a more potent anti-tumor efficacy.-
公开(公告)号：EP2341908B1
公开(公告)日：2016-04-13
申请号：EP08875931.1
申请日：2008-09-26
IPC分类号： A61P35/00
CPC分类号： A61K31/513 , A61K31/4745 , A61K31/519 , A61K39/39558 , A61K2300/00
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公开(公告)号：EP2335074B1
公开(公告)日：2013-03-20
申请号：EP08875930.3
申请日：2008-09-26
IPC分类号： G01N33/574 , G01N33/94
CPC分类号： G01N33/94 , G01N33/57419 , G01N2800/52
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7.发明授权USE OF THE OLFACTOMEDIN-4 PROTEIN (OLFM4) IN COLORECTAL CANCER DIAGNOSIS 有权奥法贝丁-4蛋白（OLFM4）在大肠癌诊断中的应用
公开(公告)号：EP2681330B1
公开(公告)日：2017-12-27
申请号：EP11719644.4
申请日：2011-03-02
IPC分类号： C12Q1/68
CPC分类号： G01N33/57488 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , A61K33/24 , A61K39/395 , A61K39/39558 , A61K45/06 , C12Q1/6886 , C12Q2600/118 , G01N33/57419 , G01N2001/284 , A61K2300/00
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公开(公告)号：EP1712643B9
公开(公告)日：2016-12-21
申请号：EP06290592.2
申请日：2006-04-12
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/142 , C12Q2600/158 , C12Q2600/16
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