公开(公告)号：EP1351940B1

公开(公告)日：2007-07-25

申请号：EP02700323.5

申请日：2002-01-15

申请人： Institut de Recherche pour le Développement ( IRD) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： FAKHFAKH, Mohamed ,  FIGADERE, Bruno ,  FOURNET, Alain ,  FRANCK, Xavier ,  HOCQUEMILLER, Reynald ,  PRINA, Eric

IPC分类号： C07D215/04 ,  A61K31/47 ,  A61P33/02 ,  C07D215/02 ,  C07D215/12 ,  C07D215/24 ,  C07D405/06 ,  C07F7/08

CPC分类号： C07D215/04 ,  A61K31/47 ,  C07D215/12 ,  C07D215/14 ,  C07D215/24 ,  C07D405/06 ,  C07F7/0812 ,  Y02A50/409 ,  Y02A50/411

摘要： The invention relates to the use of quinolines having general formula (I), wherein R1 denotes H; alkyl C1-C15; alkenyl or alkynyl C2-C15; -CHO; heteroaryl; alkyl C1-C15 or alkenyl or alkynyl C2-C7 comprising at least one substituent selected from among O, halogen, -OH, -CHO, -COOH, aryloxycarbonyl, alkyloxycarbonyl C2-C8, alkenyloxycarbonyl C3-C9, nitrile, aryl, heteroaryl, arylsulphone, alkylsulphone C1-C7, thioalkyl or aminoalkyl C1-C7; alkenyl C2-C7 bearing at least one substituent selected from among NH2, alcoxy C1-C7, phenoxy, cycloalkyl C3-C6 or heteroaryloxy; alkenyl or alkynyl C2-C15 comprising at least one trialkylsilyl C1-C7; R2, in position 3, 6 or 8, denotes H; halogen; -OH; -CHO; -COOH; alkyl or alcoxy C1-C7; -NH2; alkenyl C2-C7; or alkynyl C2-C10; R1 and R2 do not both denote H. The invention is used for the preparation of a medicine to treat protozoan and retrovirus co-infections.