专利检索 ap:("Instituto Biomar S.A.") AND inv:"MARÍN VIEIRA, Maria del Carmen" 第 1 页

1.

发明公开
COMPOUNDS FOR THE MANAGEMENT OF CELL STEMNESS AND INVASION IN CANCER AND RELATED DISEASES 审中-公开

公开(公告)号：EP4349409A1

公开(公告)日：2024-04-10

申请号：EP22382943.3

申请日：2022-10-06

申请人： Instituto Biomar S.A.

发明人： VILLOCH FERNÁNDEZ, Javier , MARQUÉS MARTÍNEZ, Margarita M. , MARÍN VIEIRA, Maria del Carmen , MARTÍN LÓPEZ, Marta , SÁNCHEZ LÓPEZ, José María , FERNÁNDEZ MEDARDE, Antonio , VINUESA NAVARRO, María de los Angeles , CAÑEDO HERNÁNDEZ, María Librada

IPC分类号： A61P35/00 , C07D493/04 , C12N1/14 , A61K31/353

摘要： The present invention relates to compound of general formula (I):

wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP73 and stemness- and invasiveness-related genes. The compounds may be isolated from the fermentation broth of a fungal strain of Chaetomium sp., or are derivatives thereof. The strain of Chaetomium sp. HT-GU-SUES-904 with accession number CECT 20840 is also claimed.