公开(公告)号：EP3937931A1

公开(公告)日：2022-01-19

申请号：EP20712264.9

申请日：2020-03-12

申请人： Instituto Biomar S.A.

发明人： FERNÁNDEZ MEDARDE, Antonio ,  VINUESA NAVARRO, María de los Ángeles ,  SÁNCHEZ LÓPEZ, José María ,  BOLAÑOS HERNÁNDEZ, Juan Pedro ,  ALMEIDA PARRA, María de los Ángeles ,  FERNÁNDEZ SÁNCHEZ, Emilio

IPC分类号： A61K31/407 ,  A61K9/00 ,  A61P25/28 ,  A61P39/06

公开(公告)号：EP3708162A1

公开(公告)日：2020-09-16

申请号：EP19382179.0

申请日：2019-03-12

申请人： Instituto Biomar S.A.

发明人： FERNÁNDEZ MEDARDE, Antonio ,  VINUESA NAVARRO, María de los Ángeles ,  SÁNCHEZ LÓPEZ, José María ,  BOLAÑOS HERNÁNDEZ, Juan Pedro ,  ALMEIDA PARRA, María de los Ángeles ,  FERNANDEZ SANCHEZ, Emilio

IPC分类号： A61K31/407 ,  A61K9/00 ,  A61P25/28 ,  A61P39/06

摘要： Compounds of general formula

wherein
the wavy bond ∼ is either a double bond or the epoxide,

or pharmaceutically acceptable salts, solvates, tautomers, or stereoisomers thereof, for use in the treatment of diseases associated with oxidative stress.

公开(公告)号：EP4349409A1

公开(公告)日：2024-04-10

申请号：EP22382943.3

申请日：2022-10-06

申请人： Instituto Biomar S.A.

发明人： VILLOCH FERNÁNDEZ, Javier ,  MARQUÉS MARTÍNEZ, Margarita M. ,  MARÍN VIEIRA, Maria del Carmen ,  MARTÍN LÓPEZ, Marta ,  SÁNCHEZ LÓPEZ, José María ,  FERNÁNDEZ MEDARDE, Antonio ,  VINUESA NAVARRO, María de los Angeles ,  CAÑEDO HERNÁNDEZ, María Librada

IPC分类号： A61P35/00 ,  C07D493/04 ,  C12N1/14 ,  A61K31/353

摘要： The present invention relates to compound of general formula (I):

wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine, particularly in cancer such as Glioblastoma. The compounds have shown to be useful in therapy as modulators of TAP73 and stemness- and invasiveness-related genes. The compounds may be isolated from the fermentation broth of a fungal strain of Chaetomium sp., or are derivatives thereof. The strain of Chaetomium sp. HT-GU-SUES-904 with accession number CECT 20840 is also claimed.

公开(公告)号：EP3656762A1

公开(公告)日：2020-05-27

申请号：EP18382856.5

申请日：2018-11-26

申请人： Instituto Biomar S.A. ,  Universidad Autónoma de Madrid

发明人： FERNÁNDEZ MEDARDE, Antonio ,  VINUESA NAVARRO, María de los Ángeles ,  SÁNCHEZ LÓPEZ, José María ,  CAÑEDO HERNÁNDEZ, Librada María ,  FRESNO ESCUDERO, Manuel ,  SÁNCHEZ -VALDEPEÑAS VILLEGAS, Carmen María

IPC分类号： C07D209/52 ,  A61K31/403 ,  A61P29/00

摘要： The invention relates to a family of fungal compounds which are inhibitors of NF-κB inducing kinase and are thus useful in the treatment of NF-κB-related diseases or disorders such as inflammatory or autoimmune diseases or disorders.

公开(公告)号：EP3019472A1

公开(公告)日：2016-05-18

申请号：EP14736831.0

申请日：2014-07-08

申请人： Instituto Biomar S.A.

发明人： FERNÁNDEZ MEDARDE, Antonio ,  CAÑEDO HERNÁNDEZ, Librada María ,  VINUESA-NAVARRO, María De Los Ángeles ,  SÁNCHEZ LÓPEZ, José María ,  CALVO PELAZ, Belinda ,  MARTÍNEZ INSUA, Marta ,  RODRÍGUEZ QUESADA, Ana ,  GARCÍA CABALLERO, Melissa ,  MEDINA TORRES, Miguel Ángel

IPC分类号： C07D209/70 ,  A61K31/403 ,  A61P35/00

CPC分类号： C07D209/70

摘要： The invention refers to compounds of general formula (I) wherein the variables take the various meanings, pharmaceutical compositions containing them and their use in medicine: The compounds have shown to be useful in therapy as angiogenesis inhibitors. The compounds are isolated from the fermentation broth of a fungal strain
Paraconiothyrium sp., or are derivatives thereof.

摘要翻译： 本发明涉及通式（I）的化合物，其中变量取各种含义，含有它们的药物组合物及其在药物中的用途。 这些化合物已被证明可用于治疗作为血管生成抑制剂。 这些化合物从真菌菌纲Paraconiothyrium sp。的发酵液中分离，或是其衍生物。