公开(公告)号：EP1520587B1

公开(公告)日：2011-06-29

申请号：EP03724819.2

申请日：2003-05-08

申请人： Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros ,  CENTRO NACIONAL DE BIOPREPARADOS

发明人： Lastre González, Miriam de San Juan ,  Pérez Martín, Oliver Germán ,  Labrada Rosado, Alexis ,  Bidot Martínez, Igor ,  Pérez Lastre, Jorge Ernesto ,  Bracho Granada, Gustavo Rafael ,  Del Campo Alonso, Judith Mónica ,  Pérez Lastre, Dainerys Aleida ,  Facenda Ramos, Elisa ,  Zayas Vignier, Caridad ,  Rodríguez Martínez, Claudio ,  Sierra Gonzàlez, Victoriano Gustavo

IPC分类号： A61K39/39 ,  A61K39/35

CPC分类号： A61K39/35 ,  A61K2039/55505 ,  A61K2039/55583 ,  A61K2039/55594 ,  A61K2039/57 ,  A61K2039/6018

摘要： The invention relates to the field of immunology, immunoallergy and, in particular, the use of adjuvants or carriers in order to modulate the immunological response to allergens. The technical objective of the invention is: to produce a therapeutic or prophylactic pharmaceutical preparation using bacterial proteoliposomes, which, when applied to allergic individuals, transforms the Th2- and IgE-dependent allergic response into a protective Th1 response; and to prevent the appearance and development of allergies in not-yet allergic individuals. The vaccine composition consists of proteoliposomes of gram-negative bacteria coupled with allergens and, optionally, other antigens or adjuvants. The invention also relates to the method of producing the inventive vaccine composition and to the two-dose schedule for immunisation with said vaccine composition.

公开(公告)号：EP1520587A1

公开(公告)日：2005-04-06

申请号：EP03724819.2

申请日：2003-05-08

申请人： Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros ,  Centro Nacional de Biopreparados

发明人： Lastre Gonzalez, Miriam de San Juan ,  Perez Martin, Oliver Germán ,  Labrada Rosado, Alexis ,  Bidot Martinez, Igor ,  Perez Lastre, Jorge Ernesto ,  Bracho Granada, Gustavo Rafael ,  Del Campo Alonso, Judith Monica ,  Perez Lastre, Dainerys Aleida ,  Facenda Ramos, Elisa ,  Zayas Vignier, Caridad ,  Rodriguez Martinez, Claudio ,  Sierra Gonzélez, Victoriano Gustavo

IPC分类号： A61K39/39 ,  A61K39/35

CPC分类号： A61K39/35 ,  A61K2039/55505 ,  A61K2039/55583 ,  A61K2039/55594 ,  A61K2039/57 ,  A61K2039/6018

摘要： The present invention rebates to the field of Immunology, specifically with the branch of Immuno-Allergy and in particular with the use of adjuvant or carrier compounds, capable of modulating the immune response to allergens. The technical objective that is pursued is to obtain a pharmaceutical preparation of therapeutic or prophylactic use using bacterial proteoliposomes, which transform the allergic response Th2 and IgE when being applied in allergic individuals, toward a protector response Th1; as well as it is able to prevent the appearance and the development of allergies in individuals non-allergic yet. The vaccine composition consists of proteoliposomes derived from Gram-negative bacteria coupled to allergens and optionally contains other adjuvants or antigens. The method for its preparation and an immunization scheme of two doses are provided.

摘要翻译： 本发明回扣免疫学领域，特别是与免疫过敏分支，特别是与使用的辅助剂或载体的化合物，能够调节对变应原的免疫应答。 该技术目标是追求所做的是使用细菌的脂蛋白体，其中变换当被施加在过敏性个体价值，朝向Th1应答保护变应性Th2应答和IgE，以获得治疗或预防用途的药物制剂; 以及它能够防止出现过敏的个人价值不过敏的发展呢。 疫苗组合物从耦合到过敏原的革兰氏阴性细菌衍生的脂蛋白体besteht并任选含有其它佐剂或抗原。 提供了用于其制备方法和两种剂量的免疫方案的方法。