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1.发明公开A FACTOR INCREASING EFFICIENCY OF A DNA VACCINE AGAINST A VIRUS, A PLASMID DNA FORMULATION, A DNA VACCINE, A METHOD OF OBTAINING A MODIFIED EXPRESSION VECTOR AND USE OF A NUCLEOTIDE SEQUENCE RECOGNISED BY THE NF KAPPA B FACTOR 审中-公开因子提高DNA疫苗对病毒，质粒DNA制剂，DNA疫苗，获得修饰表达载体的方法以及由NF KAPPA B因子识别的核苷酸序列的用途的效率
公开(公告)号：EP3268033A1
公开(公告)日：2018-01-17
申请号：EP15745258.2
申请日：2015-07-09
发明人： SIRKO, Agnieszka , GÓRA-SOCHACKA, Anna , ZAGÓRSKI-OSTOJA, Wlodzimierz , STACHYRA, Anna , REDKIEWICZ, Patrycja , MIDOUX, Patrick , PICHON, Chantal
CPC分类号： A61K39/12 , A61K2039/53 , C12N2760/16134 , C12N2800/106 , C12N2810/10
摘要： The invention is related to a factor increasing efficiency of a DNA vaccine aimed against a virus, a plasmid DNA preparation, a DNA vaccine, a method of obtaining a modified 3NFKB expression vector and use of a nucleotide sequence recognised by NFKB. More particularly, the provided solution is related to use of a DNA sequence recognised by the NF kappa B nuclear transcription factor (NFKB,nuclear factor kappa B) in a vaccine in order to ensure effective vaccine plasmid transport into the nucleus and to enhance transcription levels of the introduced gene-coding a selected antigen.
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