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1.发明公开USE OF CATIONIC DERIVATIVES OF POLYPRENOLS PTAI IN PRODUCTION OF IMMUNOMODULATING SUBSTANCES 审中-公开聚丙烯酸酯PTAI阳离子衍生物在免疫调节物质生产中的应用
公开(公告)号：EP3185893A1
公开(公告)日：2017-07-05
申请号：EP15739689.6
申请日：2015-06-12
申请人： Instytut Biochemii I Biofizyki Pan , Uniwersytet Jagiellonski , Instytut Chemii Organicznej Pan
发明人： GÓRA-SOCHACKA, Anna , STACHYRA, Anna , SIRKO, Agnieszka , ZAGÓRSKI-OSTOJA, Wlodzimierz , REDKIEWICZ, Patrycja , GAWARECKA, Katarzyna , CHOJNACKI, Tadeusz , SKORUPINSKA-TUDEK, Karolina , KULA-SWIEZEWSKA, Ewa , RAK, Monika , MADEJA, Zbigniew , MASNYK, Marek , CHMIELEWSKI, Marek , OCHALEK, Anna
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： A61K39/12 , A61K39/145 , A61K2039/53 , A61K2039/552 , A61K2039/55511 , A61K2039/6018 , C12N2760/16134
摘要： The presented invention is related to a vaccine, a pharmaceutical composition, a carrier for nucleic acids and for other biologically active substances, use of composition in vaccine manufacturing and use of cationic derivatives of PTAI in production of immunomodulating substances. More specifically, the presented invention is related to use of carriers based on cationic derivatives of polyprenols used as DNA vaccine carriers, easily transported and stored.
摘要翻译： 本发明涉及疫苗，药物组合物，用于核酸和其他生物活性物质的载体，组合物在疫苗生产中的用途以及PTAI的阳离子衍生物在免疫调节物质生产中的用途。 更具体地说，本发明涉及使用基于用作DNA疫苗载体的聚异戊烯醇的阳离子衍生物的载体，其易于运输和储存。
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2.发明公开A FACTOR INCREASING EFFICIENCY OF A DNA VACCINE AGAINST A VIRUS, A PLASMID DNA FORMULATION, A DNA VACCINE, A METHOD OF OBTAINING A MODIFIED EXPRESSION VECTOR AND USE OF A NUCLEOTIDE SEQUENCE RECOGNISED BY THE NF KAPPA B FACTOR 审中-公开因子提高DNA疫苗对病毒，质粒DNA制剂，DNA疫苗，获得修饰表达载体的方法以及由NF KAPPA B因子识别的核苷酸序列的用途的效率
公开(公告)号：EP3268033A1
公开(公告)日：2018-01-17
申请号：EP15745258.2
申请日：2015-07-09
发明人： SIRKO, Agnieszka , GÓRA-SOCHACKA, Anna , ZAGÓRSKI-OSTOJA, Wlodzimierz , STACHYRA, Anna , REDKIEWICZ, Patrycja , MIDOUX, Patrick , PICHON, Chantal
CPC分类号： A61K39/12 , A61K2039/53 , C12N2760/16134 , C12N2800/106 , C12N2810/10
摘要： The invention is related to a factor increasing efficiency of a DNA vaccine aimed against a virus, a plasmid DNA preparation, a DNA vaccine, a method of obtaining a modified 3NFKB expression vector and use of a nucleotide sequence recognised by NFKB. More particularly, the provided solution is related to use of a DNA sequence recognised by the NF kappa B nuclear transcription factor (NFKB,nuclear factor kappa B) in a vaccine in order to ensure effective vaccine plasmid transport into the nucleus and to enhance transcription levels of the introduced gene-coding a selected antigen.
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