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公开(公告)号：EP4321617A2
公开(公告)日：2024-02-14
申请号：EP23199206.6
申请日：2017-11-22
IPC分类号： C12N9/22
摘要： This invention pertains to recombinant AsCpf1 and LbCpf1 nucleic acids and polypeptides for use in CRISPR/Cpf1 endonuclease systems and mammalian cell lines encoding recombinant AsCpf1 or LbCpf1 polypeptides. The invention includes recombinant ribonucleoprotein complexes and CRSPR/Cpf1 endonuclease systems having a suitable AsCpf1 crRNA is selected from a length-truncated AsCpf1 crRNA, a chemically-modified AsCpf1 crRNA, or an AsCpf1 crRNA comprising both length truncations and chemical modifications. Methods of performing gene editing using these systems and reagents are also provided.
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公开(公告)号：EP3545085A1
公开(公告)日：2019-10-02
申请号：EP17873549.4
申请日：2017-11-22
IPC分类号： C12N9/22 , C12N15/10 , C12N15/113 , C12N15/90
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公开(公告)号：EP4321617A3
公开(公告)日：2024-04-24
申请号：EP23199206.6
申请日：2017-11-22
IPC分类号： C12N15/55 , C12N15/10 , C12N15/113 , C12N15/90 , C12N9/22
CPC分类号： C12N15/102 , C12N15/113 , C12N15/63 , C12N15/90 , C12N15/111 , C12N9/22 , C12N2310/2020170501 , C12Y301/30
摘要： This invention pertains to recombinant AsCpf1 and LbCpf1 nucleic acids and polypeptides for use in CRISPR/Cpf1 endonuclease systems and mammalian cell lines encoding recombinant AsCpf1 or LbCpf1 polypeptides. The invention includes recombinant ribonucleoprotein complexes and CRSPR/Cpf1 endonuclease systems having a suitable AsCpf1 crRNA is selected from a length-truncated AsCpf1 crRNA, a chemically-modified AsCpf1 crRNA, or an AsCpf1 crRNA comprising both length truncations and chemical modifications. Methods of performing gene editing using these systems and reagents are also provided.
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">4.发明公开
公开(公告)号：EP4185708A2
公开(公告)日：2023-05-31
申请号：EP21755231.4
申请日：2021-07-22
发明人： MCNEILL, Matthew , TURK, Rolf , RETTIG, Garrett , BLACK, Ellen , SUN, Yongming , SAILOR, Chris , WANG, Yu , GUNDERSON, Keith , KINNEY, Kyle
IPC分类号： C12Q1/6811 , C12Q1/6869 , C12N15/113
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