公开(公告)号：EP1568706A1

公开(公告)日：2005-08-31

申请号：EP04004408.3

申请日：2004-02-26

申请人： Intercept Pharmaceuticals, Inc.

发明人： Pellicciari, Roberto

IPC分类号： C07J9/00

CPC分类号： C07J9/005

摘要： The invention relates to a FXR agonist of formula (I):
   and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof.

摘要翻译： 本发明涉及式（I）的FXR激动剂：其化学上可接受的盐，溶剂合物或氨基酸缀合物。

公开(公告)号：EP2698375B1

公开(公告)日：2018-02-21

申请号：EP13192394.8

申请日：2009-11-19

申请人： Intercept Pharmaceuticals, Inc.

发明人： Pellicciari, Roberto

IPC分类号： C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  A61K31/575 ,  A61P1/16

CPC分类号： C07J9/005 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00

摘要： The invention relates to compounds of Formula A: (A) or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer and gastrointestinal disease.

公开(公告)号：EP2698375A2

公开(公告)日：2014-02-19

申请号：EP13192394.8

申请日：2009-11-19

申请人： Intercept Pharmaceuticals, Inc.

发明人： Pellicciari, Roberto

IPC分类号： C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  A61K31/575 ,  A61P1/16

CPC分类号： C07J9/005 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00

摘要： The invention relates to compounds of Formula A: (A) or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer and gastrointestinal disease.

公开(公告)号：EP2698375A3

公开(公告)日：2014-03-12

申请号：EP13192394.8

申请日：2009-11-19

申请人： Intercept Pharmaceuticals, Inc.

发明人： Pellicciari, Roberto

IPC分类号： C07J9/00 ,  C07J31/00 ,  C07J41/00 ,  A61K31/575 ,  A61P1/16

CPC分类号： C07J9/005 ,  C07J9/00 ,  C07J31/00 ,  C07J41/00

摘要： The invention relates to compounds of Formula A: (A) or a salt, solvate, hydrate, or prodrug thereof. The compounds of Formula A are TGR5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer and gastrointestinal disease.

摘要翻译： 本发明涉及式A的化合物：（A）或其盐，溶剂合物，水合物或前药。 式A化合物是用于治疗各种疾病，包括代谢疾病，炎性疾病，肝脏疾病，自身免疫性疾病，心脏疾病，肾脏疾病，癌症和胃肠疾病的TGR5调节剂。

公开(公告)号：EP1392714B1

公开(公告)日：2005-08-31

申请号：EP02750526.2

申请日：2002-02-21

申请人： Intercept Pharmaceuticals, Inc.

发明人： Pellicciari, Roberto

IPC分类号： C07J9/00 ,  A61K31/575 ,  A61P9/10

CPC分类号： C07J9/005 ,  C07C215/08 ,  C07C215/10 ,  C07C215/12 ,  C07J9/00 ,  C07J41/0055 ,  C07J43/00 ,  Y10S514/893

摘要： The invention relates to compounds of formula (I): wherein R is ethyl and pharmaceutically acceptable salts, solvates or amino acid conjugates thereof. The compounds of formula (I) are useful as FXR agonists.