公开(公告)号：EP3865146A1

公开(公告)日：2021-08-18

申请号：EP19868580.2

申请日：2019-10-04

申请人： International Institute of Cancer Immunology, Inc. ,  Sumitomo Dainippon Pharma Co., Ltd.

发明人： SUGIYAMA Haruo

IPC分类号： A61K38/04 ,  A61K39/39 ,  A61K48/00 ,  A61P35/00 ,  C07K14/82 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/12

摘要： The present disclosure provides a composition for preventing or treating a benign tumor. Provided is a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a specific embodiment, the present disclosure provides a composition for preventing or treating a benign tumor that comprises a WT1 peptide or an analog thereof, or a nucleic acid molecule encoding a WT1 peptide or an analog thereof. In a preferred embodiment, the composition for preventing or treating a benign tumor (e.g. familial adenomatous polyposis) according to the present disclosure comprises a killer type WT1 peptide and/or a helper type WT1 peptide. In a further preferred embodiment, the WT1 peptide is WT1 126 killer peptide and/or WT1 35 helper peptide. In another aspect, provided are a method of inducing WT1 peptide-specific CTLs, a method of inducing WT1-specific helper T cells, and a method of inducing dendritic cells presenting a WT1 peptide.