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1.发明公开COMBINATION ANTICANCER ENDOWED WITH ANTITUMOR ACTIVITY, COMPRISING ALKALOIDS OF CHELIDONIUM MAJUS 审中-公开具有抗肿瘤活性的组合抗癌剂，包含胆碱钠盐的生物碱
公开(公告)号：EP3250235A1
公开(公告)日：2017-12-06
申请号：EP16715865.8
申请日：2016-01-29
申请人： International Society for Drug Development S.r.l. , Advanced Molecular Biological Computation S.r.l.
发明人： BATISTONI, Renata , BIANUCCI, Anna Maria Paola , FERRARI, Alessio , MADAU, Pierluigi , LUBINU, Giuseppe , MARRACCI, Silvia , NATALI, Marco , PURICELLI, Guido
IPC分类号： A61K45/06 , A61K31/4745 , A61K31/485 , A61K31/495 , A61K31/7068 , A61K36/66 , A61P35/00
CPC分类号： A61K45/06 , A61K31/4745 , A61K31/485 , A61K31/495 , A61K31/7068 , A61K36/66 , A61K2300/00
摘要： The invention relates to a combination having antitumor activity, wherein an agent having antineoplastic activity, such as gemcitabine or temozolomide, is associated with an alkaloid of
Chelidonium majus (
C. majus ), such as berbenne, chelidonine or protopine.-
2.发明公开
公开(公告)号：EP3468556A1
公开(公告)日：2019-04-17
申请号：EP17734646.7
申请日：2017-06-08
IPC分类号： A61K31/435 , A61K31/4439 , A61K35/00
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公开(公告)号：EP3969436A1
公开(公告)日：2022-03-23
申请号：EP20715687.8
申请日：2020-03-10
发明人： PURICELLI, Guido , RAPPOSELLI, Simona , CHIELLINI, Grazia , COLUMBANO, Amedeo , PERRA, Andrea , RUNFOLA, Massimiliano , GUL, Sheraz
IPC分类号： C07C217/80 , C07C233/15 , C07C233/25 , C07D207/00 , A61P1/16
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公开(公告)号：EP3731835A1
公开(公告)日：2020-11-04
申请号：EP18795301.3
申请日：2018-10-08
IPC分类号： A61K31/13 , A61K31/26 , A61K31/385 , A61P25/16 , A61P25/28 , C07D339/04
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5.发明公开2-OXO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE COMPOUNDS AND THEIR USE AS INHIBITORS OF PDK1 审中-公开2-氧代-1,2-二氢吡啶-3-羧酰胺化合物及其作为PDK1抑制剂的用途
公开(公告)号：EP3307726A1
公开(公告)日：2018-04-18
申请号：EP16735586.6
申请日：2016-06-10
IPC分类号： C07D401/12 , A61K31/435 , A61K31/4439 , A61P35/00
CPC分类号： C07D401/12 , A61K31/4439 , A61P35/00
摘要： The present invention concern a 2-oxo-1,2-dihydropyridine-3-carboxamide compound of Formula (I) and new 2-oxo-1,2-dihydropyridine-3-carboxamide compounds of Formula (II) in the treatment of pathologies which require an inhibitor of PDK1 enzyme such as diabetes, neurodegenerative diseases such as Alzheimer's and Prion Diseases, and tumours such as breast, and pancreatic cancers and glioblastoma, particularly glioblastoma.
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公开(公告)号：EP3204002A1
公开(公告)日：2017-08-16
申请号：EP15787905.7
申请日：2015-10-06
IPC分类号： A61K31/282 , A61K31/337 , A61K31/395 , A61K31/404 , A61K31/4178 , A61K31/4725 , A61K31/506 , A61K31/513 , A61K31/65 , A61P35/00
CPC分类号： A61K31/4725 , A61K31/282 , A61K31/337 , A61K31/395 , A61K31/404 , A61K31/4178 , A61K31/506 , A61K31/513 , A61K31/65 , A61K2300/00
摘要： The invention concerns a combination comprising at least one 2-oxo-indole derivative of formula (I) in which R1 is selected from the group consisting of thienyl, imidazolyl and pyridyl, optionally substituted by (C1-C3) alkyl, A is a -CH2CO- o -SO2- group; R is selected from the group consisting of 6,7-dimethoxy-1,2,3,4- tetrahydroisoquinolinyl, 3,4-dimethoxy-benzylamino, (C1-C3)alkyl, benzyl or a pharmaceutically acceptable salt thereof and at least one antitumor drug. The combination is for use in the treatment of tumors, in particular glioblastoma multiforme (GBM), breast tumor and pancreatic tumor. The combination is effective in the treatment of resistant tumor forms.
摘要翻译： 本发明涉及包含至少一种式（I）的2-氧代 - 吲哚衍生物的组合，其中R 1选自任选被（C 1 -C 3）烷基取代的噻吩基，咪唑基和吡啶基，A是 - CH2CO-o-SO2-基团; R选自6,7-二甲氧基-1,2,3,4-四氢异喹啉基，3,4-二甲氧基 - 苄基氨基，（C1-C3）烷基，苄基或其药学上可接受的盐和至少一种 抗肿瘤药物。 该组合用于治疗肿瘤，特别是多形性成胶质细胞瘤（GBM），乳腺肿瘤和胰腺肿瘤。 该组合在治疗抗性肿瘤形式中是有效的。
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