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1.发明授权LACTOBACILLUS glyceraldehyde-3-phosphate dehydrogenase PROMOTERS AND USES THEREOF 有权甘油醛-3-磷酸脱氢酶 - PROMOTOREN von LACTOBACILLUS UND IHRE VERWENDUNG
公开(公告)号：EP2483409B1
公开(公告)日：2017-03-22
申请号：EP10765600.1
申请日：2010-09-27
CPC分类号： C07K14/335 , C07K14/315 , C12N9/0008 , C12N9/90 , C12N15/746 , C12P21/02
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公开(公告)号：EP4034144A1
公开(公告)日：2022-08-03
申请号：EP20786609.6
申请日：2020-09-25
IPC分类号： A61K35/747 , A61K39/00 , A23K10/18 , A61K35/745 , A61K39/39 , A61P37/08
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公开(公告)号：EP2758512B1
公开(公告)日：2018-05-09
申请号：EP12772891.3
申请日：2012-09-21
IPC分类号： C12N1/04 , C12R1/225 , A61K35/74 , C12N9/10 , C12N15/74 , A61K38/00 , A61K35/744 , C07K14/325 , C12P19/12 , C12N1/20 , C12N15/86 , A61K39/00 , A23L33/135
CPC分类号： C12N9/1051 , A23L33/135 , A23V2002/00 , A61K35/744 , A61K38/00 , A61K2039/522 , C07K14/325 , C12N1/04 , C12N1/20 , C12N15/746 , C12N15/86 , C12P19/12 , C12Y204/01216
摘要： The present invention relates to a gram positive bacterium, preferably a lactic acid bacterium (LAB) or Bifidobacterium, with increased stress resistance and/or improved manufacturing, processing and/or storage characteristics. In particular, the invention relates to a gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further lack cellobiose-specific PTS system IIC component (ptcC) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：EP3382006A1
公开(公告)日：2018-10-03
申请号：EP18172371.9
申请日：2012-09-21
CPC分类号： C12N1/20 , A23C9/1234 , A23K10/18 , A23L33/135 , A23Y2220/00 , A23Y2300/00 , A61K2039/523 , C07K14/315 , C12N1/04 , C12N9/1051 , C12N9/16 , C12P19/12 , C12R1/01 , C12R1/225 , C12Y204/01216 , Y02P20/52
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：EP2758513B1
公开(公告)日：2018-05-16
申请号：EP12773253.5
申请日：2012-09-21
CPC分类号： C12N1/20 , A23C9/1234 , A23K10/18 , A23L33/135 , A23Y2220/00 , A23Y2300/00 , A61K2039/523 , C07K14/315 , C12N1/04 , C12N9/1051 , C12N9/16 , C12P19/12 , C12R1/01 , C12R1/225 , C12Y204/01216 , Y02P20/52
摘要： The present invention relates to gram positive bacteria with increased stress resistance and/or improved storage characteristics. In particular, the invention relates to gram positive bacterium which accumulate intracellular trehalose. The gram positive bacterium according to the invention lack cellobiose-specific PTS system IIC component (PtcC) activity. The gram positive bacterium may further lack trehalose 6-phosphate phosphorylase (TrePP) activity. The gram positive bacterium may further overexpress trehalose transporters. The invention further relates to compositions comprising such gram positive bacterium as well as methods and uses thereof.
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公开(公告)号：EP2714912B1
公开(公告)日：2018-05-02
申请号：EP12729396.7
申请日：2012-06-01
CPC分类号： C12N15/746 , C12N15/74
摘要： The invention relates to polycistronic expression in gram-positive bacterium and in particular concerns polycistronic expression units comprising one or more gene endogenous to the gram-positive bacterium transcriptionally coupled to one or more genes exogenous to the bacterium.
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