公开(公告)号：EP4101531A1

公开(公告)日：2022-12-14

申请号：EP21750951.2

申请日：2021-01-27

申请人： Inventage Lab Inc.

发明人： KIM, Ju Hee ,  KIM, Dong Hoon ,  CHON, Chan Hee

IPC分类号： B01J19/00 ,  A61K9/16

摘要： The present invention disclosed herein relates to a microparticle producing system using microfluidics and a controlling method thereof, and specifically, to a microparticle producing system that may stably transport droplets produced using microfluidics without agglomeration or destruction, compared to the conventional art, and a method of controlling the microparticle producing system to transport the droplets more stably in the microparticle producing system. By the microparticle producing system and the controlling method thereof, which are disclosed herein, droplets produced by the microparticle producing system using microfluidics may be stably transported without agglomeration or destruction, resulting in more effective microparticle production.

公开(公告)号：EP4378573A1

公开(公告)日：2024-06-05

申请号：EP22849851.5

申请日：2022-07-26

申请人： Inventage Lab. Inc.

发明人： LEE, Sanghun ,  KIM, Ju Hee ,  KIM, Dong Hoon ,  CHON, Chan Hee

IPC分类号： B01F33/30 ,  B01F33/3011 ,  B01F25/00 ,  B01F23/80 ,  B01L3/00 ,  B01F101/22 ,  B82Y5/00

CPC分类号： B01F25/00 ,  B01F23/80 ,  B01F33/30 ,  B01F33/3011 ,  B01F2101/2220220101 ,  B01L3/00 ,  B82Y5/00

摘要： The lipid nanoparticles manufacturing chip comprises a first raw material supply flow path, a second raw material supply flow path, and a mixer portion connected to the first raw material supply flow path and the second raw material supply flow path, and mixing a first raw material supplied through the first raw material supply flow path and a second raw material supplied through the second raw material supply flow path. The mixer portion comprises a first stabilizing unit, and a first mixing unit connected to the first stabilizing unit and mixing the first raw material and the second raw material with each other. Mixing of the first raw material and the second raw material is performed more in the first mixing unit than in the first stabilizing unit.

公开(公告)号：EP4268917A1

公开(公告)日：2023-11-01

申请号：EP21911309.9

申请日：2021-12-03

申请人： Inventage Lab. Inc.

发明人： KIM, Ju Hee ,  CHON, Chan Hee

IPC分类号： B01D11/04 ,  B01D1/30 ,  B01D35/02 ,  A61K9/16 ,  B01D1/14 ,  B01D3/34 ,  B01D17/02 ,  C08F6/00 ,  C08F6/10

摘要： This solvent-removing apparatus comprises: a tank body accommodating an emulsion comprising first source material in a continuous phase and second source material in a dispersed phase; a fluid supply unit for supplying fluid into the tank body to cause the emulsion to circulate; and a discharge unit for discharging the gas in the tank body to the outside.

公开(公告)号：EP4252900A1

公开(公告)日：2023-10-04

申请号：EP21898279.1

申请日：2021-08-02

申请人： Inventage Lab. Inc.

发明人： KIM, Ju Hee ,  CHON, Chan Hee

IPC分类号： B01J2/02 ,  A61K9/16 ,  A61K9/107

摘要： a system for producing a microsphere includes a first raw material storing part in which a first raw materil is stored, a second raw material storing part in which a second raw material including a solvent, a biodegradable polymer, and a drug is stored, an emulsion generating part configured to continuously form an emulsion including the first raw material of a continuous phase and the second raw material of a dispersed phase, a first solvent extracting and removing part configured to accommodate the emulsion formed from the emulsion generating part, and extract and remove the solvent from the dispersed phase of the emulsion to form a microsphere, and a second solvent extracting and removing part which is spaced apart from the first solvent extracting and removing part, configured to accommodate the emulsion formed from the emulsion generating part, and extract and remove the solvent from the dispersed phase of the emulsion to form a microsphere.

公开(公告)号：EP4303176A1

公开(公告)日：2024-01-10

申请号：EP22792066.7

申请日：2022-04-22

申请人： Inventage Lab Inc.

发明人： PARK, Hyochan ,  CHON, Chan Hee ,  KIM, Donghoon ,  KIM, Ju Hee

IPC分类号： B82B3/00 ,  C12N15/113 ,  C12N15/88 ,  B82Y40/00

摘要： The present disclosure relates to a method for manufacturing lipid nanoparticles and an apparatus for manufacturing the same, which are capable of increasing a production yield in a subsequent eradication filtration process and the like by not requiring a separate process for sorting the manufactured lipid nanoparticles.
In addition, by deviating from an existing optimal drug and lipid ratio, a content of ionizable lipid that causes a problem of toxicity when injected into the body may be lowered, and uniform-sized lipid nanoparticles may be manufactured.

公开(公告)号：EP4241884A1

公开(公告)日：2023-09-13

申请号：EP22807840.8

申请日：2022-05-11

申请人： Inventage Lab. Inc.

发明人： HAN, Euidon ,  CHON, Chan Hee ,  KIM, Dong Hoon ,  KIM, Ju Hee

IPC分类号： B01L3/00 ,  B01F33/30 ,  B01F33/301 ,  B01F25/00 ,  B01F23/80

摘要： A lipid nanoparticles manufacturing chip comprises a mixer unit for forming a mixed solution by mixing a first raw material containing an active ingredient and a second raw material containing a lipid, a dilution unit that is connected to the mixer unit and dilutes the mixed solution using a diluent solution to make a diluted mixed solution, and a concentration unit connected to the dilution unit and for obtaining a concentrated solution by concentrating lipid nanoparticles (LNP) from the diluted mixed solution.