专利检索 ap:("Ionis Pharmaceuticals, Inc." OR "Ercole Biotech, Inc.") AND inv:"DEAN, Nicholas, M." 第 1 页

1.

发明授权
CHIMERIC OLIGOMERIC COMPOUNDS FOR MODULATION OF SPLICING 有权
标题翻译： CHIMERE OLIGOMERE VERBINDUNGEN ZUR MODULATION VON SPLICING

公开(公告)号：EP1937312B1

公开(公告)日：2016-06-29

申请号：EP06802842.2

申请日：2006-08-29

申请人： Ionis Pharmaceuticals, Inc. , Ercole Biotech, Inc.

发明人： BENNETT, C. Frank , DEAN, Nicholas, M. , KOLE, Ryszard , KOPCZYNSKI, Casey, C.

IPC分类号： C12N15/11 , C12N15/113

CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2320/33 , C12N2310/3525 , C12N2310/3533 , C12N2310/3531

2.

发明公开
CHIMERIC OLIGOMERIC COMPOUNDS FOR MODULATION OF SPLICING 有权
标题翻译： CHIMERE低聚物化合物调制剪接

公开(公告)号：EP1937312A2

公开(公告)日：2008-07-02

申请号：EP06802842.2

申请日：2006-08-29

申请人： Isis Pharmaceuticals, Inc. , Ercole Biotech, Inc.

发明人： BENNETT, C. Frank , DEAN, Nicholas, M. , KOLE, Ryszard , KOPCZYNSKI, Casey, C.

IPC分类号： A61K48/00

CPC分类号： C12N15/113 , C12N15/111 , C12N15/1135 , C12N2310/321 , C12N2310/322 , C12N2310/346 , C12N2320/33 , C12N2310/3525 , C12N2310/3533 , C12N2310/3531

摘要： Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.