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公开(公告)号：EP2218727B1
公开(公告)日：2014-12-24
申请号：EP10075221.1
申请日：2004-06-02
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
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2.发明公开Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression 审中-公开表达的酰基辅酶A胆固醇ACYLTRAN转移酶-2反义调节
公开(公告)号：EP2332955A3
公开(公告)日：2011-09-07
申请号：EP10176479.3
申请日：2002-07-15
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y203/01026 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
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公开(公告)号：EP2453016A1
公开(公告)日：2012-05-16
申请号：EP11192464.3
申请日：2007-11-27
发明人： Freier, Susan M. , Crooke, Rosanne M. , Graham, Mark J. , Tarbet, Kristina Lemonidis , Bhanot, Sanjay , Tribble, Diane , Watt, Andrew T.
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , A01K2227/105 , A01K2267/0375 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
摘要翻译： 本文公开了用于降低具有升高的LDL-C的个体中的LDL-C的反义化合物和方法。 另外公开了用于治疗高胆固醇血症或可选地用于治疗或预防动脉粥样硬化的反义化合物和方法。 还公开了用于降低冠心病风险的反义化合物和方法。 此类方法包括向需要治疗的个体施用靶向PCSK9核酸的反义化合物。 所给予的反义化合物包括gapmer反义寡核苷酸。
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公开(公告)号：EP2441449A1
公开(公告)日：2012-04-18
申请号：EP11185507.8
申请日：2004-04-15
IPC分类号： A61K31/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
摘要翻译： 提供化合物，组合物和方法用于调节载脂蛋白C-III的表达。 组合物包含靶向编码载脂蛋白C-III的核酸的寡核苷酸。 提供了使用这些化合物调节载脂蛋白C-III表达和用于诊断和治疗与载脂蛋白C-III表达相关的疾病的方法。
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公开(公告)号：EP2441449B1
公开(公告)日：2015-10-14
申请号：EP11185507.8
申请日：2004-04-15
IPC分类号： A61K31/00
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/11 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/351 , C12N2320/30 , C12N2330/31 , C12N2310/3521
摘要： Compounds, compositions and methods are provided for modulating the expression of apolipoprotein C-III. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein C-III. Methods of using these compounds for modulation of apolipoprotein C-III expression and for diagnosis and treatment of disease associated with expression of apolipoprotein C-III are provided.
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公开(公告)号：EP2455471A3
公开(公告)日：2012-09-12
申请号：EP11192458.5
申请日：2007-11-27
发明人： Freier, Susan M. , Crooke, Rosanne M. , Graham, Mark J. , Tarbet, Kristina Lemonidis , Bhanot, Sanjay , Tribble, Diane , Watt, Andrew T.
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , A01K2227/105 , A01K2267/0375 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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公开(公告)号：EP2455471A2
公开(公告)日：2012-05-23
申请号：EP11192458.5
申请日：2007-11-27
发明人： Freier, Susan M. , Crooke, Rosanne M. , Graham, Mark J. , Tarbet, Kristina Lemonidis , Bhanot, Sanjay , Tribble, Diane , Watt, Andrew T.
IPC分类号： C12N15/11
CPC分类号： C12N15/1137 , A01K2227/105 , A01K2267/0375 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating hypercholesterolemia, or alternatively for treating or preventing atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
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8.发明公开Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression 审中-公开反式调节剂表达缬氨酸 - 丙氨酰 - 胆碱酯酶 - ACYLTRAN SFERASE-2
公开(公告)号：EP2332955A2
公开(公告)日：2011-06-15
申请号：EP10176479.3
申请日：2002-07-15
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y203/01026 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of acyl CoA cholesterol acyltransferase-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding acyl CoA cholesterol acyltransferase-2. Methods of using these compounds for modulation of acyl CoA cholesterol acyltransferase-2 expression and for treatment of diseases associated with expression of acyl CoA cholesterol acyltransferase-2 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节酰基辅酶A胆固醇酰基转移酶-2的表达。 组合物包含靶向编码酰基辅酶A胆固醇酰基转移酶-2的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节酰基辅酶A胆固醇酰基转移酶-2表达和治疗与酰基辅酶A胆固醇酰基转移酶-2表达相关疾病的方法。
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公开(公告)号：EP2272985A1
公开(公告)日：2011-01-12
申请号：EP10175588.2
申请日：2002-08-05
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein(a). The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein(a). Methods of using these compounds for modulating of apolipoprotein(a) expression and for treatment of diseases associated with expression of apolipoprotein(a) are provided.
摘要翻译： 提供了用于调节载脂蛋白（a）表达的反义化合物，组合物和方法。 该组合物包含靶向编码载脂蛋白（a）的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节载脂蛋白（a）表达和治疗与载脂蛋白（a）表达相关的疾病的方法。
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公开(公告)号：EP2218727A1
公开(公告)日：2010-08-18
申请号：EP10075221.1
申请日：2004-06-02
CPC分类号： C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译： 提供化合物，组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C反应蛋白表达和诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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