Genetically modified organisms for the production of lipids
    3.
    发明公开
    Genetically modified organisms for the production of lipids 审中-公开
    Genetisch modifizierte有机体zur Herstellung von Lipiden

    公开(公告)号:EP2292741A1

    公开(公告)日:2011-03-09

    申请号:EP09075393.0

    申请日:2009-08-26

    摘要: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.

    摘要翻译: 本发明提供了一种分离的遗传修饰的非哺乳动物生物体,其中酰基-CoA:固醇酰基转移酶/甾醇O-酰基转移酶(EC 2.3.1.26)和/或二酰基甘油酰基转移酶/二酰基甘油O-酰基转移酶(EC 2.3.1.20)和 /或卵磷脂胆固醇酰基转移酶/磷脂:二酰基甘油酰基转移酶(EC 2.3.1.158)和/或酰基辅酶A蜡醇酰基转移酶(EC 2.3.1.75)与相应的野生型生物相比被减少或消除,使用这种 有机体,用于制造这种生物体的穿梭载体和用于生产这种生物体的方法。

    GENETICALLY MODIFIED ORGANISMS FOR THE PRODUCTION OF LIPIDS
    6.
    发明公开
    GENETICALLY MODIFIED ORGANISMS FOR THE PRODUCTION OF LIPIDS 有权
    GENETISCH MODIFIZIERTE ORGANISMEN ZUR HERSTELLUNG VON LIPIDEN

    公开(公告)号:EP2470647A1

    公开(公告)日:2012-07-04

    申请号:EP10747819.0

    申请日:2010-08-04

    摘要: The invention provides an isolated genetically modified non-mammalian organism, wherein the activity of acyl-CoA:sterol acyltransferase/sterol O-acyltransferase (EC 2.3.1.26) and/or diacylglycerol acyltransferase/diacylglycerol O-acyltranferase (EC 2.3.1.20) and/or lecithin cholesterol acyl transferase/phospholipid: diacylglycerol acyltransferase (EC 2.3.1.158) and/or acyl CoA-wax alcohol acyltransferase (EC 2.3.1.75) is reduced or abolished in comparison with a corresponding wildtype organism, methods of use of such an organism, shuttle vehicles for making such an organism and methods for producing such an organism.

    摘要翻译: 本发明提供了一种分离的遗传修饰的非哺乳动物生物体,其中酰基-CoA:固醇酰基转移酶/甾醇O-酰基转移酶(EC 2.3.1.26)和/或二酰基甘油酰基转移酶/二酰基甘油O-酰基转移酶(EC 2.3.1.20)和 /或卵磷脂胆固醇酰基转移酶/磷脂:二酰基甘油酰基转移酶(EC 2.3.1.158)和/或酰基辅酶A蜡醇酰基转移酶(EC 2.3.1.75)与相应的野生型生物相比被减少或消除,使用这种 有机体,用于制造这种生物体的穿梭载体和用于生产这种生物体的方法。