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    (E)-N-MONOALKYL-3-OXO-3-(2-THIENYL)PROPENAMINE AND PROCESS FOR PRODUCING THE SAME AND (E,Z)-N-MONOALKYL-3-OXO-3-(2-THIENYL)PROPENAMINE AND PROCESS FOR PRODUCING THE SAME
    2.
    发明公开
    (E)-N-MONOALKYL-3-OXO-3-(2-THIENYL)PROPENAMINE AND PROCESS FOR PRODUCING THE SAME AND (E,Z)-N-MONOALKYL-3-OXO-3-(2-THIENYL)PROPENAMINE AND PROCESS FOR PRODUCING THE SAME 有权
    （E）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺和维生素E衍生物，UND（E，Z）-N-单烷基-3-氧-3-（2-噻吩基）丙胺 VERFAHREN ZU DEREN HERSTELLUNG

    公开(公告)号：EP1916243A4

    公开(公告)日：2009-09-09

    申请号：EP06782103

    申请日：2006-08-01

    申请人： SUMITOMO SEIKA CHEMICALS

    发明人： SATAKE SYUZO ,  HAYASHIZAKA NORIYUKI ,  FUSEYA ICHIRO ,  TANAKA MUNEAKI ,  KAGANO HIROKAZU

    IPC分类号： C07D333/22

    CPC分类号： C07D333/22

    摘要： It is intended to provide a process for producing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine represented by the general formula (I): (wherein R represents an alkyl group having 1 to 4 carbon atoms), characterized by maintaining a solution in which (Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine is dissolved in a solvent at 25°C or lower thereby to deposit crystals and fractionating a crystal with a particle size of 100 µm or less from the deposited crystals; and a process for producing (E,Z)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine, characterized by adding a water-insoluble organic solvent to a reaction solution obtained by reacting an alkali metal salt of β-oxo-β-(2-thienyl) propanal with a monoalkylamine compound, adding a seed crystal containing (E)-N-monoalkyl-3-oxo-3-(2-thienyl)propenamine to an organic layer obtained by separation and maintaining the temperature at 25°C or lower.

    摘要翻译： 其意图是提供用于制备由通式（I）表示的（E）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺的方法：（其中R表示具有1至4个碳的烷基 （Z）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺在25℃以下溶解于溶剂中而使晶体析出，并用 沉积的晶体的粒径为100μm或更小; （E，Z）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺的制造方法，其特征在于，向通过使β，β-不饱和羧酸碱金属盐反应而得到的反应溶液中添加非水溶性有机溶剂， （E）-N-单烷基-3-氧代-3-（2-噻吩基）丙烯胺的晶种加入到通过分离和保持所获得的有机层中的方法 温度在25°C或更低。