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1.发明公开Method of manufacturing 2'-3'-dideoxy-2',3'.didehydronucleosides 失效Verfahren zur Herstellung von 2'，3'-二脱氧-2'，3'-二脱氢核苷酸。
公开(公告)号：EP0504868A1
公开(公告)日：1992-09-23
申请号：EP92104773.4
申请日：1992-03-19
发明人： Ebata, Takashi, c/o JAPAN TOBACCO INC. , Matsushita, Hajime, c/o JAPAN TOBACCO INC. , Mizutani, Nobuhiro, c/o YUKI GOSEI KOGYO CO., LTD. , Ohki, Junji, c/o YUKI GOSEI KOGYO CO., LTD. , Tanaka, Junko, c/o YUKI GOSEI KOGYO CO., LTD. , Kaibara, Hiromi c/o YUKI GOSEI KOGYO CO., LTD. , Itoh, Kazuo c/o YUKI GOSEI KOGYO CO., LTD.
摘要： A method of manufacturing 2',3'-dideoxy-2',3'-didehydronucleosides by reacting a ribonucleoside derivative, whose furanose ring has 5-position hydroxyl protected by a silyl protective group, with acid anhydride such as acetic anhydride in the presence of a catalyst such as hydrous zirconium oxide, and then by subjecting the reaction product to decarboxylation. The decarboxylation can be effected by heating the reaction product. This method can be performed in a single step, and requires no use of reagents which are expensive or chemicals which should be handled with care. Hence, it serves to manufacture 2',3'-dideoxy-2',3'-didehydronucleosides easily at low cost.
摘要翻译： 通过使呋喃糖环具有由甲硅烷基保护基保护的5-位羟基的核糖核苷衍生物与酸酐如乙酸酐反应制备2'，3'-二脱氧-2'，3'-二脱氢核苷的方法， 的催化剂如含水氧化锆，然后使反应产物脱羧。 脱羧可以通过加热反应产物来实现。 该方法可以在一个步骤中进行，并且不需要使用昂贵的试剂或应小心处理的化学品。 因此，以低成本容易地制造2'，3'-二脱氧-2'，3'-二氢核苷。
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2.发明授权
公开(公告)号：EP0504868B1
公开(公告)日：1996-11-06
申请号：EP92104773.4
申请日：1992-03-19
发明人： Ebata, Takashi, c/o JAPAN TOBACCO INC. , Matsushita, Hajime, c/o JAPAN TOBACCO INC. , Mizutani, Nobuhiro, c/o YUKI GOSEI KOGYO CO., LTD. , Ohki, Junji, c/o YUKI GOSEI KOGYO CO., LTD. , Tanaka, Junko, c/o YUKI GOSEI KOGYO CO., LTD. , Kaibara, Hiromi c/o YUKI GOSEI KOGYO CO., LTD. , Itoh, Kazuo c/o YUKI GOSEI KOGYO CO., LTD.
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