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1.发明公开Cells expressing a chimera receptor and their uses 审中-公开Zellen，die einchimärischenRezeptor exprimieren，und deren Verwendungen
公开(公告)号：EP0950710A2
公开(公告)日：1999-10-20
申请号：EP99106794.3
申请日：1999-04-06
CPC分类号： C07K14/72 , C07K14/715 , C07K2319/00 , C07K2319/02
摘要： The present invention provides a chimera gene as constructed by fusing the gene for the extracelluar region of human growth hormone receptor with the genes for the transmembrane and cytoplasmic regions of thrombopoietin receptor, an expression plasmid for the said gene and animal cells capable of expressing the protein encoded by the said gene.
The human-growth-hormone dependent animal cell line transformed with an expression plasmid for the said gene are useful in screening hormones which show affinity for the chimera receptor, as well as their agonists and antagonists.摘要翻译： 本发明提供了通过将人生长激素受体的细胞外区域的基因与血小板生成素受体的跨膜和细胞质区域的基因融合而构建的嵌合体基因，所述基因的表达质粒和能够表达蛋白质的动物细胞 由所述基因编码。 用所述基因的表达质粒转化的人生长激素依赖性动物细胞系可用于筛选对嵌合体受体以及它们的激动剂和拮抗剂显示亲和力的激素。
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公开(公告)号：EP0950710A3
公开(公告)日：1999-10-27
申请号：EP99106794.3
申请日：1999-04-06
CPC分类号： C07K14/72 , C07K14/715 , C07K2319/00 , C07K2319/02
摘要： The present invention provides a chimera gene as constructed by fusing the gene for the extracelluar region of human growth hormone receptor with the genes for the transmembrane and cytoplasmic regions of thrombopoietin receptor, an expression plasmid for the said gene and animal cells capable of expressing the protein encoded by the said gene.
The human-growth-hormone dependent animal cell line transformed with an expression plasmid for the said gene are useful in screening hormones which show affinity for the chimera receptor, as well as their agonists and antagonists.摘要翻译： 本发明提供了通过将人生长激素受体的细胞外区域的基因与血小板生成素受体的跨膜和胞质区域的基因融合而构建的嵌合体基因，所述基因的表达质粒和能够表达该蛋白质的动物细胞 由所述基因编码。 用所述基因的表达质粒转化的人生长激素依赖性动物细胞系可用于筛选对嵌合受体显示亲和性的激素以及它们的激动剂和拮抗剂。
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