公开(公告)号：EP2825200A1

公开(公告)日：2015-01-21

申请号：EP13761537.3

申请日：2013-03-14

申请人： Janssen Biotech, Inc.

发明人： CHEN, John ,  FRANSSON, Johan ,  FURSOV, Natalie ,  HAMEL, Damon ,  MALIA, Thomas ,  OBMOLOVA, Galina ,  ORT, Tatiana ,  RYCYZYN, Michael ,  SCULLY, Michael ,  SWEET, Raymond ,  TEPLYAKOV, Alexey ,  WHEELER, John ,  ALMAGRO, Juan Carlos

IPC分类号： A61K39/395

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.