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公开(公告)号:EP2794654B1
公开(公告)日:2019-05-22
申请号:EP12859920.6
申请日:2012-12-19
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公开(公告)号:EP2493506B1
公开(公告)日:2019-04-10
申请号:EP10827516.5
申请日:2010-10-29
发明人: NASO, Michael , SWEET, Raymond , LUO, Jinquan , WU, Sheng-jiun , ELLOSO, Merle , DUCATA, Daniela, Della , RAUCHENBERGER, Robert , RUTZ, Mark , ALMAGRO, Juan, Carlos , TAUDTE, Susann , WU, Bingyuan , OBMOLOVA, Galina , MALIA, Thomas
IPC分类号: A61K39/395 , C07K16/00 , C07K16/24
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公开(公告)号:EP2794654A2
公开(公告)日:2014-10-29
申请号:EP12859920.6
申请日:2012-12-19
发明人: ALDERFER, Christopher , JANECKI, Dariusz , LIU, Xuesong , MURDOCK, Melissa , WU, Sheng-Jiun , MERCKEN, Marc , VANDERMEEREN, Marc , MALIA, Thomas
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要: The present invention relates to anti-PHF-tau antibodies and methods of making and using them.
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公开(公告)号:EP2493506A2
公开(公告)日:2012-09-05
申请号:EP10827516.5
申请日:2010-10-29
发明人: NASO, Michael , SWEET, Raymond , LUO, Jinquan , WU, Sheng-jiun , ELLOSO, Merle , DUCATA, Daniela, Della , RAUCHENBERGER, Robert , RUTZ, Mark , ALMAGRO, Juan, Carlos , TAUDTE, Susann , WU, Bingyuan , OBMOLOVA, Galina , MALIA, Thomas
IPC分类号: A61K39/395 , C07K16/00
CPC分类号: C07K16/244 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要: Interleukin-17A (IL-17A) antibody antagonists, polynucleotides encoding IL-17A antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.
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公开(公告)号:EP3578567A1
公开(公告)日:2019-12-11
申请号:EP19173615.6
申请日:2012-12-19
发明人: ALDERFER, Christopher , JANECKI, Dariusz , LIU, Xuesong , MURDOCK, Melissa , WU, Sheng-Jiun , MERCKEN, Marc , VANDERMEEREN, Marc , MALIA, Thomas
摘要: The present invention relates to anti-PHF tau antibodies and methods of making and using them.
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公开(公告)号:EP2825200A1
公开(公告)日:2015-01-21
申请号:EP13761537.3
申请日:2013-03-14
发明人: CHEN, John , FRANSSON, Johan , FURSOV, Natalie , HAMEL, Damon , MALIA, Thomas , OBMOLOVA, Galina , ORT, Tatiana , RYCYZYN, Michael , SCULLY, Michael , SWEET, Raymond , TEPLYAKOV, Alexey , WHEELER, John , ALMAGRO, Juan Carlos
IPC分类号: A61K39/395
CPC分类号: C07K16/2878 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
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