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1.发明公开
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公开(公告)号：EP2922872A1
公开(公告)日：2015-09-30
申请号：EP13856592.4
申请日：2013-11-21
发明人： CHIU, Mark , MOORES, Sheri , NEIJSSEN, Joost , PARREN, Paul , SCHUURMAN, Janine
IPC分类号： C07K16/00
CPC分类号： C07K16/2863 , A61K31/437 , A61K31/4545 , A61K31/517 , A61K31/5377 , A61K33/24 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2318/20 , A61K2300/00
摘要： Bispecific EGFR/c-Met antibodies and methods of making and using the molecules.
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3.发明公开COMPOSITIONS AND METHODS FOR PHAGOCYTE DELIVERY OF ANTI-STAPHYLOCOCCAL AGENTS 审中-公开组合物和方法的抗PHAGOZYTENFREISETZUNG葡萄球菌MEDIUM
公开(公告)号：EP3080161A2
公开(公告)日：2016-10-19
申请号：EP14869703.0
申请日：2014-12-09
发明人： TORRES, Victor J. , BREZSKI, Randall J. , LYNCH, Anthony , STROHL, William , WHITAKER, Brian , CHIU, Mark , BUCKLEY, Peter T. , SORING, Keri , KINDER, Michelle
IPC分类号： C07K16/12 , G01N33/569
CPC分类号： C07K16/1271 , C07K14/78 , C07K2317/30 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2318/00 , C07K2319/70 , G01N33/56938 , G01N2469/10
摘要： The present application generally relates to multi-specific molecules that bind to multiple bacterial virulence factors, methods for producing these binding molecules, and the use of these binding molecules to treat bacterial infections. In particular, the binding molecules comprise at least two binding domains, preferably an antibody or antibody fragment and an alternative scaffold. The first binding domain is capable of binding to a glycosylated staphylococcal surface protein, preferably an SDR-containing protein. The second binding domain is capable of binding to a staphylococcal leukotoxin, preferably LukAB, LukD or LukE. These multi-specific binding compounds have killing activity against staphylococci and, thus, can be used in the treatment and/or amelioration of a Staphylococcus infection, including methicillin-resistant Staphylococcus aureus.
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公开(公告)号：EP4420727A3
公开(公告)日：2024-10-23
申请号：EP23214289.3
申请日：2013-11-21
发明人： CHIU, Mark , MOORES, Sheri , NEIJSSEN, Joost , PARREN, Paul , SCHUURMAN, Janine
IPC分类号： C07K16/00 , A61K39/395 , A61K31/4545 , A61K31/517 , A61K45/06 , A61K31/437 , A61K31/5377 , A61K33/24 , C07K16/28 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/71 , C07K14/78
摘要： Bispecific EGFR/c-Met antibodies and methods of making and using the molecules.
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公开(公告)号：EP3808767A1
公开(公告)日：2021-04-21
申请号：EP20197551.3
申请日：2013-11-21
发明人： CHIU, Mark , MOORES, Sheri , NEIJSSEN, Joost , PARREN, Paul , SCHUURMAN, Janine
IPC分类号： C07K16/00 , A61K39/395 , A61K31/4545 , A61K31/517 , A61K45/06 , A61K31/437 , A61K31/5377 , A61K33/24 , C07K16/28 , A61P35/00
摘要： Bispecific EGFR/c-Met antibodies and methods of making and using the molecules.
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6.发明公开
公开(公告)号：EP3634486A2
公开(公告)日：2020-04-15
申请号：EP18814314.3
申请日：2018-06-04
发明人： CHIU, Mark , ZWOLAK, Adam
IPC分类号： A61K39/395 , C12N15/09 , C12N5/10 , C07K16/12 , C07K16/46
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公开(公告)号：EP4420727A2
公开(公告)日：2024-08-28
申请号：EP23214289.3
申请日：2013-11-21
发明人： CHIU, Mark , MOORES, Sheri , NEIJSSEN, Joost , PARREN, Paul , SCHUURMAN, Janine
IPC分类号： A61P35/00
CPC分类号： A61K2039/50520130101 , C07K2317/3120130101 , C07K2317/7320130101 , C07K2317/7620130101 , C07K2318/2020130101 , A61K39/395 , A61K31/4545 , C07K16/2863 , A61K31/517 , A61K45/06 , A61K31/437 , A61K31/5377 , A61P35/00 , A61P35/04 , A61P43/00 , A61K33/243
摘要： Bispecific EGFR/c-Met antibodies and methods of making and using the molecules.
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8.发明公开
公开(公告)号：EP3408293A1
公开(公告)日：2018-12-05
申请号：EP17744941.0
申请日：2017-01-27
发明人： CHIU, Mark , NEMETH-SEAY, Jennifer , ORT, Tatiana , SHEN, Fang
CPC分类号： C07K16/468 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/241 , C07K16/244 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific anti-TNF-α/IL-17A antibodies and anti-TNF-α antibodies, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：EP2922872B1
公开(公告)日：2018-10-10
申请号：EP13856592.4
申请日：2013-11-21
发明人： CHIU, Mark , MOORES, Sheri , NEIJSSEN, Joost , PARREN, Paul , SCHUURMAN, Janine
IPC分类号： C07K16/00 , A61K39/395 , A61K31/4545 , A61K31/517 , A61K45/06 , A61K31/437 , A61K31/5377 , A61K33/24 , C07K16/28 , A61P35/00
CPC分类号： C07K16/2863 , A61K31/437 , A61K31/4545 , A61K31/517 , A61K31/5377 , A61K33/24 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2318/20 , A61K2300/00
摘要： Bispecific EGFR/c-Met antibodies and methods of making and using the molecules.
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公开(公告)号：EP3447069B1
公开(公告)日：2020-09-23
申请号：EP18199421.1
申请日：2013-11-21
发明人： CHIU, Mark , MOORES, Sheri , NEIJSSEN, Joost , PARREN, Paul , SCHUURMAN, Janine
IPC分类号： C07K16/00 , A61K39/395 , A61K31/4545 , A61K31/517 , A61K45/06 , A61K31/437 , A61K31/5377 , A61K33/24 , C07K16/28 , A61P35/00
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