公开(公告)号：EP3386991B1

公开(公告)日：2020-06-03

申请号：EP16820106.9

申请日：2016-12-09

申请人： Janssen Pharmaceutica NV

发明人： ARORA, Nidhi ,  BACANI, Genesis M. ,  BARBAY, Joseph Kent ,  BEMBENEK, Scott D. ,  CAI, Min ,  CHEN, Wei ,  DECKHUT, Charlotte Pooley ,  EDWARDS, James P. ,  GHOSH, Brahmananda ,  KREUTTER, Kevin ,  LI, Gang ,  TICHENOR, Mark S. ,  VENABLE, Jennifer D. ,  WEI, Jianmei ,  WIENER, John J. M. ,  WU, Yao ,  XIAO, Kun ,  ZHANG, Feihuang ,  ZHU, Yaoping

IPC分类号： C07D495/16 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P37/00 ,  A61P19/00

公开(公告)号：EP3245208A1

公开(公告)日：2017-11-22

申请号：EP16737886.8

申请日：2016-01-14

申请人： Pharmacyclics LLC ,  Janssen Pharmaceutica NV

发明人： BENHAIM, Cyril ,  CHEN, Wei ,  GOLDMAN, Erick ,  HORVATH, Andras ,  PYE, Philip ,  SMYTH, Mark S. ,  VERNER, Erik J.

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Described herein is the synthesis of Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo [3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one.

公开(公告)号：EP3719022A1

公开(公告)日：2020-10-07

申请号：EP20177012.0

申请日：2016-12-09

申请人： Janssen Pharmaceutica NV

发明人： ARORA, Nidhi ,  BACANI, Genesis M. ,  BARBAY, Joseph Kent ,  BEMBENEK, Scott D. ,  CAI, Min ,  CHEN, Wei ,  DECKHUT, Charlotte Pooley ,  EDWARDS, James P. ,  GHOSH, Brahmananda ,  KREUTTER, Kevin ,  LI, Gang ,  TICHENOR, Mark S. ,  VENABLE, Jennifer D. ,  WEI, Jianmei ,  WIENER, John J. M. ,  WU, Yao ,  XIAO, Kun ,  ZHANG, Feihuang ,  ZHU, Yaoping

IPC分类号： C07D495/16 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P37/00 ,  A61P19/00

摘要： The present disclosure is directed to compounds of Formula (I) as Bruton's kinase inhibitors and their preparation, as well as compositions comprising compounds of Formula (I).

公开(公告)号：EP3386991A1

公开(公告)日：2018-10-17

申请号：EP16820106.9

申请日：2016-12-09

申请人： Janssen Pharmaceutica NV

发明人： ARORA, Nidhi ,  BACANI, Genesis M. ,  BARBAY, Joseph Kent ,  BEMBENEK, Scott D. ,  CAI, Min ,  CHEN, Wei ,  DECKHUT, Charlotte Pooley ,  EDWARDS, James P. ,  GHOSH, Brahmananda ,  KREUTTER, Kevin ,  LI, Gang ,  TICHENOR, Mark S. ,  VENABLE, Jennifer D. ,  WEI, Jianmei ,  WIENER, John J. M. ,  WU, Yao ,  XIAO, Kun ,  ZHANG, Feihuang ,  ZHU, Yaoping

IPC分类号： C07D495/16 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P37/00 ,  A61P19/00

摘要： The present disclosure is directed to compounds of Formula (I) as Bruton's kinase inhibitors and their preparation, as well as compositions comprising compounds of Formula (I).