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公开(公告)号：EP2493863A1
公开(公告)日：2012-09-05
申请号：EP10776483.9
申请日：2010-10-28
发明人： COATS, Steven, J. , ZHANG, Yue-mei , LIN, Shu-chen , LIU, Li , MISKOWSKI, Tamara, A. , DAX, Scott, L. , BRESLIN, Henry , DE CORTE, Bart, L. , HE, Wei
IPC分类号： C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61P25/04
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows (Formula I), wherein R
1 , Y, R
2 , R
3 , and R
a are defined herein.-
公开(公告)号：EP1833826B1
公开(公告)日：2009-05-27
申请号：EP05855276.1
申请日：2005-12-21
发明人： COATS, Steven, J , DAX, Scott, L. , DECORTE, Bart , LIU, Li , MCDONNELL, Mark , MCNALLY, James J.
IPC分类号： C07D451/04 , A61K31/46 , A61P25/04
CPC分类号： C07D451/04
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic ō-opioid modulators. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described. Formula (I).
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公开(公告)号：EP2331498B1
公开(公告)日：2016-11-09
申请号：EP09774997.2
申请日：2009-08-11
发明人： COLBURN, Raymond, W. , DAX, Scott, L. , FLORES, Christopher, M. , LUDOVICI, Donald, W. , XIA, Mingde , XU, Xiaoging , YOUNGMAN, Mark, A. , ZHU, Bin
IPC分类号： C07C237/20 , C07D209/40 , C07D215/38 , C07D231/56 , C07D261/14 , A61K31/165 , A61K31/472 , A61K31/47 , A61K31/415 , A61K31/416 , A61P29/00
CPC分类号： C07D217/04 , C07C237/20 , C07C2102/08 , C07C2602/08 , C07D215/38 , C07D217/02 , C07D401/12
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公开(公告)号：EP1910353A1
公开(公告)日：2008-04-16
申请号：EP05782009.4
申请日：2005-08-02
发明人： DAX, Scott, L. , DECORTE, Bart , LIU, Li , MCDONNELL, Mark , MCNALLY, James, J.
IPC分类号： C07D451/02 , A61K31/46 , A61P29/00
CPC分类号： C07D451/02
摘要： The invention is directed to delta opioid receptor modulators. More specifically, the invention relates to tricyclic δ-opioid modulators, of formula (I). Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.
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5.发明授权PHENOXY-SUBSTITUTED PYRIMIDINES AS OPIOID RECEPTOR MODULATORS 有权羟基取代的吡咯烷酮ALI OPIOIDREZEPTORMODULATOREN
公开(公告)号：EP2493863B1
公开(公告)日：2015-02-25
申请号：EP10776483.9
申请日：2010-10-28
发明人： COATS, Steven, J. , ZHANG, Yue-mei , LIN, Shu-chen , LIU, Li , MISKOWSKI, Tamara, A. , DAX, Scott, L. , BRESLIN, Henry , DE CORTE, Bart, L. , HE, Wei
IPC分类号： C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61P25/04
CPC分类号： C07D239/52 , A61K31/506 , C07D239/28 , C07D239/34 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP2493877B1
公开(公告)日：2014-09-17
申请号：EP10776484.7
申请日：2010-10-28
发明人： COATS, Steven, J. , BIAN, Haiyan , CONNOLLY, Peter, J. , BIGNAN, Gilles , CAI, Chaozhong , DAX, Scott, L. , DE CORTE, Bart, L. , LIN, Shu-Chen , LIU, Li , MACIELAG, Mark, J. , PITIS, Philip, M. , ZHANG, Yue-mei , ZHU, Bin , HE, Wei
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , A61K31/506 , A61P25/04
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
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7.发明公开4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS 有权4-取代的2-苯氧基苯胺δ阿片受体MOLDULATOREN
公开(公告)号：EP2493852A1
公开(公告)日：2012-09-05
申请号：EP10776485.4
申请日：2010-10-28
发明人： COATS, Steven, J. , BIAN, Haiyan , CAI, Chaozhong , DE CORTE, Bart, L. , LIU, Li , MACIELAG, Mark, J. , DAX, Scott, L. , PITIS, Philip, M. , CONNOLLY, Peter, J. , HE, Wei
IPC分类号： C07D205/04 , C07D207/09 , C07D211/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02 , C07C217/90 , A61K31/397 , A61K31/40 , A61K31/444 , A61K31/4245 , A61K31/4025
CPC分类号： C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R
1 , R
2 , R
3 , R
a , and Y are defined herein.-
公开(公告)号：EP2493877A1
公开(公告)日：2012-09-05
申请号：EP10776484.7
申请日：2010-10-28
发明人： COATS, Steven, J. , BIAN, Haiyan , CONNOLLY, Peter, J. , BIGNAN, Gilles , CAI, Chaozhong , DAX, Scott, L. , DE CORTE, Bart, L. , LIN, Shu-Chen , LIU, Li , MACIELAG, Mark, J. , PITIS, Philip, M. , ZHANG, Yue-mei , ZHU, Bin , HE, Wei
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , A61K31/506 , A61P25/04
CPC分类号： C07D239/47 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, and L, A, and Ra are defined herein.
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公开(公告)号：EP2331499B1
公开(公告)日：2016-09-21
申请号：EP09791384.2
申请日：2009-08-11
发明人： COLBURN, Raymond, W. , DAX, Scott, L. , FLORES, Christopher, M. , LUDOVICI, Donald, W. , MATHEWS, Jay, M. , XIA, Mingde , XU, Xiaoqing , YOUNGMAN, Mark, A. , ZHU, Bin
IPC分类号： C07D207/08 , C07D209/08 , C07D209/44 , C07D217/06 , C07D241/04 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10
CPC分类号： C07D207/08 , C07D209/08 , C07D209/44 , C07D217/06 , C07D241/04 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D405/10 , C07D409/04 , C07D409/06 , C07D417/06
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10.发明授权4-SUBSTITUTED-2-PHENOXY-PHENYLAMINE DELTA OPIOID RECEPTOR MODULATORS 有权4-取代的2-苯氧基苯胺δ阿片受体MOLDULATOREN
公开(公告)号：EP2493852B1
公开(公告)日：2014-04-09
申请号：EP10776485.4
申请日：2010-10-28
发明人： COATS, Steven, J. , BIAN, Haiyan , CAI, Chaozhong , DE CORTE, Bart, L. , LIU, Li , MACIELAG, Mark, J. , DAX, Scott, L. , PITIS, Philip, M. , CONNOLLY, Peter, J. , HE, Wei
IPC分类号： C07D205/04 , C07D207/09 , C07D211/56 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02 , C07C217/90 , A61K31/397 , A61K31/40 , A61K31/444 , A61K31/4245 , A61K31/4025
CPC分类号： C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
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