公开(公告)号：EP1603883B1

公开(公告)日：2012-03-28

申请号：EP04707270.7

申请日：2004-02-02

申请人： Janssen Pharmaceutica NV

发明人： CODD, Ellen ,  DAX, Scott L. ,  JETTER, Michele ,  McDONNELL, Mark ,  McNALLY, James J. ,  YOUNGMAN, Mark

IPC分类号： C07D215/38

CPC分类号： C07D215/38 ,  C07D215/60 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10

摘要： This invention is directed to vanilloid receptor VR1 ligands of formula (I). More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.