公开(公告)号：EP1506166B1

公开(公告)日：2011-11-16

申请号：EP03731189.1

申请日：2003-05-15

申请人： Janssen Pharmaceutica NV

发明人： CODD, Ellen ,  DAX, Scott, L. ,  JETTER, Michele ,  MCDONELL, Mark ,  MCNALLY, James, J. ,  YOUNGMAN, Mark

IPC分类号： C07C275/26 ,  C07C275/32 ,  C07C335/14 ,  C07D213/36 ,  C07D215/38 ,  C07D217/02 ,  C07D217/08 ,  C07D217/22 ,  C07D217/24

CPC分类号： C07D213/40 ,  C07C275/26 ,  C07C275/28 ,  C07C275/32 ,  C07C335/14 ,  C07C2601/02 ,  C07C2602/10 ,  C07D215/38 ,  C07D217/02 ,  C07D217/08 ,  C07D217/22 ,  C07D217/24 ,  C07D233/64 ,  C07D237/28 ,  C07D239/74 ,  C07D307/52 ,  C07D317/58 ,  C07D333/20 ,  C07D333/32 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

摘要： This invention is directed to vanilloid receptor VR1 ligands of formula (1). More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.

摘要翻译： 本发明涉及香草素受体VR1配体。 更具体地，本发明涉及作为VR1的有效拮抗剂或激动剂的β-氨基四氢萘衍生的脲，其可用于治疗和预防哺乳动物的炎性和其它疼痛病症。

公开(公告)号：EP1863756A1

公开(公告)日：2007-12-12

申请号：EP06739664.8

申请日：2006-03-23

申请人： Janssen Pharmaceutica NV

发明人： CODD, Ellen ,  DAX, Scott ,  FLORES, Christopher ,  JETTER, Michelle ,  YOUNGMAN, Mark

IPC分类号： C07C233/29

CPC分类号： C07D291/04 ,  C07C233/29 ,  C07C233/55 ,  C07C237/42 ,  C07D213/53 ,  C07D213/75 ,  C07D233/64 ,  C07D233/68 ,  C07D235/06 ,  C07D271/06 ,  C07D333/24 ,  C07D401/04 ,  C07D401/12

摘要： The invention is directed to novel vanilloid receptor type 1 (VR1) ligands. More specifically, the invention relates to novel biaryl-derived amides that are potent antagonists or agonists of VR1. Pharmaceutical and veterinary compositions and methods of treating mild to severe pain and various diseases using compounds of the invention are also described.

公开(公告)号：EP1603883B1

公开(公告)日：2012-03-28

申请号：EP04707270.7

申请日：2004-02-02

申请人： Janssen Pharmaceutica NV

发明人： CODD, Ellen ,  DAX, Scott L. ,  JETTER, Michele ,  McDONNELL, Mark ,  McNALLY, James J. ,  YOUNGMAN, Mark

IPC分类号： C07D215/38

CPC分类号： C07D215/38 ,  C07D215/60 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D491/10

摘要： This invention is directed to vanilloid receptor VR1 ligands of formula (I). More particularly, this invention relates to quinoline-derived amides that are potent antagonists or agonists of VR1 which are useful for the treatment and prevention of inflammatory and other pain conditions in mammals.