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1.发明公开
公开(公告)号：EP4219496A1
公开(公告)日：2023-08-02
申请号：EP23162887.6
申请日：2016-08-25
发明人： WU, Tongfei , BREHMER, Dirk , BEKE, Lijs , BOECKX, An , DIELS, Gaston, Stanislas, Marcella , GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph , LAWSON, Edward, Charles , PANDE, Vineet , PARADE, Marcus, Cornelis, Bernardus, Catharina , SCHEPENS, Wim, Bert, Griet , THURING, Johannes, Wilhelmus, John, F. , VIELLEVOYE, Marcel , SUN, Weimei , MEERPOEL, Lieven
IPC分类号： C07D471/04 , A61K31/519 , A61K31/53
摘要： The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)
wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.-
2.发明公开
公开(公告)号：EP3341368A1
公开(公告)日：2018-07-04
申请号：EP16757233.8
申请日：2016-08-25
发明人： WU, Tongfei , BREHMER, Dirk , BEKE, Lijs , BOECKX, An , DIELS, Gaston, Stanislas, Marcella , GILISSEN, Ronaldus, Arnodus, Hendrika, Joseph , LAWSON, Edward, Charles , PANDE, Vineet , PARADE, Marcus, Cornelis, Bernardus, Catharina , SCHEPENS, Wim, Bert, Griet , THURING, Johannes, Wilhelmus, John, F , VIELLEVOYE, Marcel , SUN, Weimei , MEERPOEL, Lieven
IPC分类号： C07D471/04 , A61K31/519 , A61K31/53
CPC分类号： A61K31/7076 , A61K31/5025 , A61K31/519 , A61K31/53 , A61P35/00 , C07D471/04
摘要： wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
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