公开(公告)号：EP3177319A1

公开(公告)日：2017-06-14

申请号：EP15745483.6

申请日：2015-08-03

申请人： Janssen Sciences Ireland UC

发明人： FRIJLINK, Henderik Willem ,  GRASMEIJER, Niels ,  HINRICHS, Wouter Leonardus Joseph ,  AMSSOMS, Katie Ingrid Eduard ,  BAERT, Lieven Elvire Colette

IPC分类号： A61K39/395 ,  A61K9/20

CPC分类号： A61K9/204 ,  A61K9/0024 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/522 ,  A61K31/721 ,  Y02A50/406 ,  Y02A50/463 ,  Y02A50/465 ,  Y02A50/471

摘要： The present invention relates to dosage forms comprising a compressed blend of a biologically active ingredient, one or more polymers like a poly(a-hydroxy carboxylic acid) in which optionally is incorporated a glass transition modifying agent, and optional further ingredients, wherein the polymer or polymeric mixture has a specific glass transition temperature which causes the system to be in the glassy state at ambient conditions before administration and to be in the rubbery state under the physiological conditions to which the system is exposed after administration, resulting in pulsed release of said biologically active ingredient.

摘要翻译： 本发明涉及剂型，所述剂型包含生物活性成分，一种或多种聚合物如聚（α-羟基羧酸）（其中任选引入玻璃化转变改性剂）和任选的其他成分的压缩共混物，其中所述聚合物 或聚合物混合物具有特定的玻璃化转变温度，所述玻璃化转变温度使得所述系统在施用前在环境条件下处于玻璃状态并且在施用后所述系统暴露于的生理条件下处于橡胶状态，导致所述脉冲释放所述 生物活性成分。