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公开(公告)号：EP1626053B1
公开(公告)日：2011-07-06
申请号：EP04733984.1
申请日：2004-05-19
摘要： A method of α-selective glycosylation comprising forming a cyclic protective group having a silyl acetal structure over hydroxyl groups at the 4- and 6-positions in a hexose or higher saccharide structure, which is a monosaccharide or the reducing end of an oligosaccharide (i.e., disaccharide or higher) or a sugar chain, and effecting a glycosylation reaction between this saccharide structure and an alcoholic hydroxyl or thiol group to thereby give glycosides of saccharide structure containing an α-glycoside at a high ratio. According to the above constitution, highly selective α-glycosylation in a saccharide structure can be carried out by an easy and convenient method.
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公开(公告)号：EP1626053A2
公开(公告)日：2006-02-15
申请号：EP04733984.1
申请日：2004-05-19
IPC分类号： C07H9/00
摘要： An α-selective glycosylation process of a glycosylation reaction between a sugar structure of hexose or an aldose having a chain with six or more carbon atoms in the molecule, which is a monosaccharide or a reducing end of an oligosaccharide with two or more monosaccharide residues connected by glycosidic or a sugar chain and alcoholic hydroxyl group or thiol group, to obtain a sugar structure glycoside containing α-glycoside at a high ratio, under the ring-shaped formation of a protective group in a silyl acetal structure over hydroxyl groups at positions 4 and 6 in the sugar structure.
By the process, highly selective α-glycosylation of sugar structure can be progressed in a simple and efficient manner.摘要翻译： 在分子中具有六个或更多个碳原子的链的己糖或醛糖的糖结构之间的糖基化反应的±选择性糖基化方法，其是连接有两个或更多个单糖残基的寡糖的单糖或还原末端 通过糖苷或糖链和醇羟基或硫醇基，以在高度比例的羟基上在甲硅烷基缩醛结构中形成保护基的环状形成高糖比例的糖结构糖苷 和6在糖结构。 通过该过程，糖结构的高度选择性的 - - 糖基化可以以简单有效的方式进行。
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