公开(公告)号：EP0561523A3

公开(公告)日：1993-09-29

申请号：EP93301554.7

申请日：1993-03-01

申请人： Japan Tobacco Inc.

发明人： Kodama, Hisashi, c/o Japan Tobacco Inc. ,  Hashimoto, Hironobu ,  Kajihara, Yasuhiro

IPC分类号： C07H13/04 ,  A61K31/70 ,  A61K47/48 ,  C07H15/14 ,  C07H17/04 ,  C07H15/04

CPC分类号： C07H13/04 ,  A61K47/62 ,  C07H15/04 ,  C07H15/14 ,  C07H17/04

摘要： A sialic acid-containing sugar chains' biosynthesis inhibitor is excellent in suppression of inflammation or allergy. A sialic acid-containing sugar chains' biosynthesis inhibitor comprises as an active ingredient a sugar compound of the formula (1):

wherein R¹ is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted aromatic hydrocarbon group, a peptide residue or a sugar residue, and R² is a hydrogen atom, a sulfhydryl group, an acyloxy group, an acylthio group, an aryloxy group, an alkyloxy group, a sugar residue or a glycothio residue. The sialic acid-containing sugar chains' biosynthesis inhibitor may be used as a therapeutic agent for inflammation or the like caused by the sialic acid-containing sugar chains.

公开(公告)号：EP0561523A2

公开(公告)日：1993-09-22

申请号：EP93301554.7

申请日：1993-03-01

申请人： Japan Tobacco Inc.

发明人： Kodama, Hisashi, c/o Japan Tobacco Inc. ,  Hashimoto, Hironobu ,  Kajihara, Yasuhiro

IPC分类号： C07H13/04 ,  A61K31/70 ,  A61K47/48 ,  C07H15/14 ,  C07H17/04 ,  C07H15/04

CPC分类号： C07H13/04 ,  A61K47/62 ,  C07H15/04 ,  C07H15/14 ,  C07H17/04

摘要： A sialic acid-containing sugar chains' biosynthesis inhibitor is excellent in suppression of inflammation or allergy.
A sialic acid-containing sugar chains' biosynthesis inhibitor comprises as an active ingredient a sugar compound of the formula (1):

wherein R¹ is a hydrogen atom, a substituted or unsubstituted aliphatic hydrocarbon group, a substituted or unsubstituted aromatic hydrocarbon group, a peptide residue or a sugar residue, and R² is a hydrogen atom, a sulfhydryl group, an acyloxy group, an acylthio group, an aryloxy group, an alkyloxy group, a sugar residue or a glycothio residue. The sialic acid-containing sugar chains' biosynthesis inhibitor may be used as a therapeutic agent for inflammation or the like caused by the sialic acid-containing sugar chains.

摘要翻译： 甲含唾液酸的糖链生物合成抑制剂是具有优异的炎症或过敏的抑制。 甲含唾液酸的糖链生物合成抑制剂包含作为活性成分的下式的糖化合物（1）： worin - [R <1>是一个氢原子，一个substituiertem奥德unsubstituiertem脂族烃基，substituiertem奥德unsubstituiertem 芳香族烃基，肽残基或糖残基，R <2>为氢原子，巯基，在酰硫基到酰氧基，对芳氧基，在烷氧基，糖残基或glycothio残基。 的含唾液酸的糖链生物合成抑制剂可以用作用于炎症或治疗剂等由含唾液酸的糖链引起的。