公开(公告)号：EP4360650A1

公开(公告)日：2024-05-01

申请号：EP22828537.5

申请日：2022-06-24

申请人： Japanese Foundation For Cancer Research

发明人： TAKAGI Satoshi ,  KATAYAMA Ryohei

IPC分类号： A61K45/00 ,  A61K31/192 ,  A61K31/195 ,  A61K31/40 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/7088 ,  A61P35/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53

CPC分类号： A61K31/192 ,  A61K31/195 ,  A61K31/40 ,  A61K31/42 ,  A61K31/4439 ,  A61K31/7088 ,  A61K45/00 ,  A61P35/00 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/53

摘要： It has been revealed that lysophosphatidic acid (LPA) functions as a mediator that augments invasive ability in osteosarcoma. Furthermore, it has been found that LPAR1, which is a receptor for LPA, is highly expressed in osteosarcoma and glioma, and the LPA-LPAR1 interaction is involved in the metastasis and proliferation of osteosarcoma and glioma. Examinations carried out on the basis of these findings have found that LPAR1 antagonists can serve as therapeutic agents for suppressing the metastasis and proliferation of osteosarcoma and glioma.