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公开(公告)号：EP3587452A1
公开(公告)日：2020-01-01
申请号：EP18756959.5
申请日：2018-02-26
发明人： CAO, Zhuoxiao , FU, Yayuan , ZHANG, Ting , TAO, Weikang
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , A61K39/395 , C12P21/08 , A61P35/00 , G01N33/577
摘要： The present invention provides a TIM-3 antibody, an antigen-binding fragment thereof, and medical uses thereof. Further, the present invention provides a rat-derived antibody comprising a CDR region of the TIM-3 antibody, a chimeric antibody, a human-derived antibody and a pharmaceutical composition comprising the TIM-3 antibody and an antigen-binding fragment thereof, as well as uses thereof serving as a drug. In particular, the present invention provides uses of a human-derived TIM-3 antibody in the preparation of drugs for treating TIM-3-related conditions.
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公开(公告)号：EP3604337A1
公开(公告)日：2020-02-05
申请号：EP18776535.9
申请日：2018-03-30
发明人： GU, Jinming , WANG, Xiaohua , YE, Xin , YANG, Liuqing , ZHANG, Ting , TAO, Weikang , ZHANG, Lianshan
摘要： The invention provides a B7-H3 antibody, an antigen-binding fragment thereof and a medical use thereof. Furthermore, the present invention discloses a pharmaceutical composition comprising the B7-H3 antibody or antigen-binding fragment thereof, and the use thereof as a medicament. In particular, the invention discloses a use of a human B7-H3 antibody or antigen-binding fragment thereof for the manufacture of a medicament for the treatment of B7-H3-associated disease or condition.
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公开(公告)号：EP3854816A1
公开(公告)日：2021-07-28
申请号：EP19865297.6
申请日：2019-09-25
发明人： YING, Hua , ZHANG, Ling , ZHANG, Ting , ZHANG, Lei , XU, Jianyan , TAO, Weikang
IPC分类号： C07K16/28 , A61K39/395 , A61K31/4745 , A61K31/48 , A61P35/00
摘要： Disclosed by the present invention are an anti-B7H3 antibody-exatecan analog conjugate, a preparation method therefor and an anti-tumor medicinal use thereof.
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