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1.发明公开OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF 审中-公开光学活性2-羟基四氢吡喃衍生物及其制备方法和用于制备其药物的用途
公开(公告)号：EP3290423A1
公开(公告)日：2018-03-07
申请号：EP17172160.8
申请日：2011-01-28
发明人： SUN, Hongbin , SHAN, Jiaqi , ZHANG, Boyu , YUAN, Fang
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04 , A61K31/4365 , C07B2200/07
摘要： (S)-methyl 2 -( 2 -acetoxy-6, 7 -dihydrothieno[ 3 ,2-c]pyridin- 5 ( 4 H)-yl)-2-(2-chlorophenyl)-acetate and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment results show that the present compound is useful for inhibiting platelet aggregation. The pharmacokinetic experiment results show that the present compound can be converted in vivo into pharmacologically active metabolites and is therefore useful for inhibiting platelet aggregation. Therefore, the present compound is useful for the manufacture of a medicament for preventing or treating thrombosis and embolism related diseases.
摘要翻译： （S）-2-（2-乙酰氧基-6,7-二氢噻吩并[3,2-c]吡啶-5（4H） - 基）-2-（2-氯苯基） - 乙酸甲酯及其药学上可接受的盐，制备方法和 公开了用于制造其药物的用途。 药效学实验结果显示本化合物可用于抑制血小板聚集。 药代动力学实验结果表明，本发明化合物可以在体内转化为药理活性代谢物，因此可用于抑制血小板聚集。 因此，本发明化合物可用于制备预防或治疗血栓形成和栓塞相关疾病的药物。
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2.发明公开
公开(公告)号：EP3782621A1
公开(公告)日：2021-02-24
申请号：EP18915676.3
申请日：2018-04-16
发明人： ZHAO, Yanlei , ZHANG, Jianjun , LIU, Xuefang , GAO, Yuan , SUN, Hongbin , GONG, Yanchun , LIU, Yongqiang
摘要： The present invention relates to the technical field of medicine and relates to an instant release pharmaceutical preparation of an anticoagulant and a preparation method therefor. The instant release pharmaceutical preparation of an anticoagulant comprises a vicagrel compound or a pharmaceutically acceptable form thereof, the preparation is a tablet or a capsule, the vicagrel or the pharmaceutically acceptable form thereof is pro-vided at a suitable particle size, and the D90 thereof max ) of drug absorption. Further provided by the present invention is a method for preparing an instant release pharmaceutical preparation of an anticoagulant; according to the formulation of the drug-containing particles as disclosed by the present invention, a capsule or tablet instant release preparation having excellent stability may be obtained by means of a combination of optional preparation steps.
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3.发明授权OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF 有权光学活性2-羟基四氢吡喃衍生物及其制备方法和用于制备其药物的用途
公开(公告)号：EP2532668B1
公开(公告)日：2017-05-24
申请号：EP11739328.0
申请日：2011-01-28
发明人： SUN, Hongbin , SHAN, Jiaqi , ZHANG, Boyu , YUAN, Fang
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04 , A61K31/4365 , C07B2200/07
摘要： Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by Formula I and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment results show that the present compounds of Formula I are useful for inhibiting platelet aggregation. The pharmacokinetic experiment results show that the present compound of Formula I can be converted in vivo into pharmacologically active metabolites and are therefore useful for inhibiting platelet aggregation. Therefore, the present compounds are useful for the manufacture of a medicament for preventing or treating thrombosis and embolism related diseases.
摘要翻译： 公开了由式I表示的光学活性2-羟基四氢噻吩并吡啶衍生物及其药学上可接受的盐，制备方法和在其药物制备中的用途。 药效学实验结果表明本发明的式I化合物可用于抑制血小板聚集。 药代动力学实验结果表明，本发明的式I化合物可以在体内转化成药理活性代谢物，因此可用于抑制血小板聚集。 因此，本发明化合物可用于制备用于预防或治疗血栓形成和栓塞相关疾病的药物。
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4.发明公开OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF 有权旋光2-羟基四氢噻吩吡啶衍生物，PROCESS FOR THEIR及其USE IN药品生产
公开(公告)号：EP2532668A1
公开(公告)日：2012-12-12
申请号：EP11739328.0
申请日：2011-01-28
发明人： SUN, Hongbin , SHAN, Jiaqi , ZHANG, Boyu , YUAN, Fang
IPC分类号： C07D495/04 , A61K31/4365 , A61P7/02
CPC分类号： C07D495/04 , A61K31/4365 , C07B2200/07
摘要： Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by Formula I and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment results show that the present compounds of Formula I are useful for inhibiting platelet aggregation. The pharmacokinetic experiment results show that the present compound of Formula I can be converted in vivo into pharmacologically active metabolites and are therefore useful for inhibiting platelet aggregation. Therefore, the present compounds are useful for the manufacture of a medicament for preventing or treating thrombosis and embolism related diseases.
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