专利检索 ap:("Johns Hopkins University" OR "Mold, David E." OR "Lee, Yuan C." OR "Chang, Chih-Chuan") AND inv:"HUANG, Ru Chih C., Johns Hopkins University, Department of Biology" 第 1 页

1.

发明公开
USE OF NORDIHYDROGUAIARETIC ACID DERIVATIVES IN THE TREATMENT OF DRUG RESISTANT CANCER, VIRAL AND MICROBIAL INFECTION 审中-公开
标题翻译： NORDIHYDROGUAJARETSÄUREDERIVATEN在治疗药物产生耐药性的癌症和病毒性和细菌感染USE

公开(公告)号：EP1848418A2

公开(公告)日：2007-10-31

申请号：EP05816163.9

申请日：2005-10-06

申请人： Johns Hopkins University , Mold, David E. , Lee, Yuan C. , Chang, Chih-Chuan

发明人： HUANG, Ru Chih C., Johns Hopkins University, Department of Biology , HWU, Jih-Ru c/o Department of chemistry , HSU, Ming-Hua c/o Department of Chemistry , MOLD, David E. Johns Hopkins University, Department of Biology , LEE, Yuan C. Johns Hopkins University, Department of Biology , CHANG, Chih-Chuan Johns Hopkins University, Department of Biology

IPC分类号： A61K31/192

CPC分类号： A61K31/192 , A61K31/09 , A61K31/24 , A61K31/337 , A61K31/475 , A61K31/7034 , A61K31/704 , A61K45/06 , C07H15/18 , A61K2300/00

摘要： Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections.