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    Method for improving wear resistance of polymeric bio-implantable components
    1.
    发明公开
    Method for improving wear resistance of polymeric bio-implantable components 失效
    聚合物聚合物（Verbahn zur Verbesserung der Verschleissfestigkeit von biokompatiblen Polymerkomponenten

    公开(公告)号：EP0737481A1

    公开(公告)日：1996-10-16

    申请号：EP96302327.0

    申请日：1996-04-02

    申请人： JOHNSON & JOHNSON PROFESSIONAL Inc.

    发明人： Hamilton, John V. ,  Manasas, Mark A. ,  Flynn, Timothy M.

    IPC分类号： A61L2/08 ,  B65B55/16

    CPC分类号： A61L2/081 ,  A61L2/08 ,  A61L2/082 ,  A61L2/087 ,  A61L27/16 ,  A61L2202/24 ,  B65B31/04 ,  B65B55/08 ,  B65B55/16 ,  C08L23/06

    摘要： Wear resistance and oxidation resistance of bioimplantable polymeric parts is improved by packaging the parts within flexible, gas impermeable containers while subjecting the containers and the parts to a relatively high vacuum force. The containers are heat sealed while subjected to the vacuum force such that, upon sealing, hydrostatic pressure is exerted on the part. Following sealing of the packages, the packages and their contents are irradiated to an extent sufficient to sterilize the parts and to promote crosslinking within the part. Alternatively, the same property enhancements can be imparted to polymeric parts by packaging the part within rigid or flexible containers, minimizing the oxygen content within the containers, pressurizing the containers with an inert gas, or with a mixture of hydrogen and an inert gas, to greater than 1.5 atmospheres, and irradiating the part and the container.

    摘要翻译： 生物可植入聚合物部件的耐磨性和抗氧化性通过将容器包装在柔性的气体不可渗透容器内，同时使容器和部件受到相对高的真空力的改善。 容器在受到真空力的同时被热密封，使得在密封时，在该部件上施加静水压力。 在密封包装之后，将包装及其内容物照射到足以消除零件的程度并促进部件内的交联。 或者，通过将部件包装在刚性或柔性容器内，可以将聚合物部件赋予相同的性能增强，使容器内的氧含量最小化，用惰性气体或用氢气和惰性气体的混合物对容器加压， 大于1.5个大气压，照射该部件和容器。