公开(公告)号：EP1786765B1

公开(公告)日：2009-09-02

申请号：EP04770705.4

申请日：2004-09-08

申请人： Jubilant Organosys Limited

发明人： SINGH, Govind ,  BHADWAL, Paramvir ,  JAISWAL, Sanjay ,  PANCHASARA, Dinesh, R ,  THAPER, Rajesh, Kumar ,  DUBEY, Sushil, Kumar ,  KHANNA, Jag, Mohan

IPC分类号： C07C309/30

CPC分类号： C07D309/30

摘要： The present invention relates to an improved and industrial friendly process for lactonization to produce compound of the Formula [I], from compound of the Formula [II] in presence of an inorganic compound as a suitable lactonizing agent, preferably alkali metal hydrogen sulfate, and crystallizing the obtained lactone product in a solvent; or treating compound of the Formula [II] in the presence of an inorganic compound preferably alkali metal hydrogen sulfate using phase transfer catalyst in heterogeneous phase followed by crystallizing the obtained lactone product in a solvent.

公开(公告)号：EP1979313A1

公开(公告)日：2008-10-15

申请号：EP06711364.7

申请日：2006-01-31

申请人： Jubilant Organosys Limited

发明人： GUPTA, Runjhun ,  RAM, Khushi ,  BHADWAL, Paramvir ,  THAPER, Rajesh, Kumar ,  DUBEY, Sushil, Kumar

IPC分类号： C07D207/00

CPC分类号： C07D207/34

摘要： Disclosed is a novel process for preparing pure amorphous form of Atorvastatin employing a suitable solvent system selected from water, water miscible solvents or water immiscible solvents or mixture thereof.