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11 条记录 (耗时 0.016 秒)

    METAL-ORGANIC FRAMEWORKS AS SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS
    1.
    发明公开
    METAL-ORGANIC FRAMEWORKS AS SOLID SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEMS 审中-公开

    公开(公告)号：EP4260846A1

    公开(公告)日：2023-10-18

    申请号：EP22168387.3

    申请日：2022-04-14

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： SCHELLER, Lena ,  MEINEL, Lorenz ,  LUEHMANN, Tessa

    IPC分类号： A61K9/107 ,  A61K9/00 ,  A61K47/02 ,  A61K47/22

    摘要： The present invention relates to a composition comprising a metal-organic framework, one or more emulsifier(s) and one or more lipid(s). Furthermore, the present invention relates to a method for preparing a microemulsion in response to a physical- and/or chemical stimulus and to a method for increasing the solubility of a pharmaceutically active ingredient in a solvent and/or for improving the bioavailability of a pharmaceutically active ingredient and/or for preparing a self-microemulsifying drug delivery system. Finally, the present invention relates to the use of a composition comprising a metal-organic framework, one or more emulsifier(s) and one or more lipid(s) for preparing a microemulsion in response to a physical- and/or chemical stimulus and the use of the composition for increasing the solubility of a pharmaceutically active ingredient in a solvent and/or for improving the bioavailability of a pharmaceutically active ingredient and/or for preparing a self-microemulsifying drug delivery system.

    DIAGNOSTIC CHEWING GUM FOR PATHOGENS
    5.
    发明公开
    DIAGNOSTIC CHEWING GUM FOR PATHOGENS 有权
    KAUGUMMI ZUR DIAGNOSE VON KRANKHEITSERREGER

    公开(公告)号：EP2823050A1

    公开(公告)日：2015-01-14

    申请号：EP13710333.9

    申请日：2013-03-08

    申请人： Julius-Maximilians-Universität Würzburg

    发明人： MEINEL, Lorenz ,  SCHNABELRAUCH, Matthias ,  SCHLOTTIG, Falko

    IPC分类号： C12Q1/04 ,  A61K9/00

    CPC分类号： A61K49/0004 ,  A23G4/14 ,  A61C2201/002 ,  A61K9/0058 ,  A61K49/00 ,  A61K49/0069 ,  C12Q1/04 ,  C12Q1/37 ,  C12Q2304/00 ,  G01N33/528 ,  G01N33/68 ,  G01N33/6893 ,  Y02A50/54 ,  Y02A50/58

    摘要： Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.

    摘要翻译： 本文描述的是用于鉴定通过口可检测的病原体的存在的诊断性口香糖，特别是存在于使用者的鼻，口咽，喉，食管，眼和/或肺组织中的病原体，特别是选自病毒， 细菌，原生动物，朊病毒，真菌或其组合。 本发明的诊断口香糖包括嵌入和/或附着到基底材料的基底材料或颗粒（3）和元件（1,5-7） 连接到基材和/或颗粒上的可释放风味分子，用于产生用户可直接检测的口香糖的变化，其中元件（1,5-7）在直接或间接接触时产生变化 具有由病原体释放的标记物（4），或者在病毒或朊病毒的情况下由宿主的细胞结构产生。