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    Anti HTLV-III (strain MN) monoclonal antibody
    3.
    发明公开
    Anti HTLV-III (strain MN) monoclonal antibody 失效
    单克隆抗体

    公开(公告)号：EP0465979A1

    公开(公告)日：1992-01-15

    申请号：EP91110884.3

    申请日：1991-07-01

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Eda, Yasuyuki ,  Osatomi, Kiyoshi ,  Shiosaki, Kouichi ,  Tokiyoshi, Sachio ,  Matsushita, Shuzo ,  Hattori, Toshio ,  Takatsuki, Kiyoshi

    IPC分类号： C12P21/08 ,  C12N5/20 ,  A61K39/395 ,  G01N33/569 ,  G01N33/577

    CPC分类号： C07K16/1063 ,  A61K38/00

    摘要： A monoclonal antibody capable of binding to a glycoprotein antigen having a molecular weight of about 12 x 10⁴ daltons (gp120) present in the envelope of human immunodeficiency virus (HIV) and capable of substantially neutralizing the HIV, or fragments thereof, which has the characteristics of immunoblobulin class IgG, κ, being capable of binding to glycoprotein antigen having a molecular weight of 12 x 10⁴ daltons (gp120) of HTLV-III MN , being capable of recognizing at least one epitope which is present in the region of the amino acid sequence 303 to 325 of gp120 of HTLV-III MN , being capable of binding to the surface of HTLV-III MN viral particles and thereby inhibiting the infection of the viral particles to CD4-positive cells, and being capable of binding to the surface of cells infected with HTLV-IIIMN and thereby inhibiting the syncytium formation induced by interaction between the infected cells and uninfected cells, said monoclonal antibody being useful for the prophylaxis, treatment and diagnosis of AIDS.

    摘要翻译： 能够结合存在于人免疫缺陷病毒（HIV）包膜中的分子量为约12×10 4道尔顿（gp120）的糖蛋白抗原的能够基本上中和HIV或其片段的单克隆抗体，其能够 具有能够结合分子量为12×10 4道尔顿（gp120）的HTLV-IIIMN的糖蛋白抗原的免疫球蛋白类型IgG，κ的特征，能够识别至少存在于 HTLV-IIIMN的gp120的氨基酸序列303〜325的区域，能够结合HTLV-IIIMN病毒颗粒的表面，从而抑制病毒颗粒感染CD4阳性细胞，并能够结合到 感染HTLV-IIIMN的细胞表面，从而通过感染细胞和未感染细胞之间的相互作用抑制合胞体形成，所述单克隆抗体可用于预防 艾滋病的治疗和诊断。

    Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation
    5.
    发明公开
    Gene fragments coding for the variable region of an anti-HIV antibody, chimeric anti-HIV antibodies expressed using the same, and process for their preparation 失效
    编码由这些嵌合抗-HIV抗体和它们的制备方法表示的抗HIV抗体的可变区基因片段。

    公开(公告)号：EP0327000A2

    公开(公告)日：1989-08-09

    申请号：EP89101583.6

    申请日：1989-01-30

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Tokiyoshi, Sachio ,  Matsushita, Shuzo ,  Hattori, Toshio ,  Takatsuki, Kiyoshi

    IPC分类号： C12N15/13 ,  A61K39/395 ,  C12N5/10 ,  C12P21/08

    CPC分类号： C07K16/1063 ,  A61K38/00 ,  C07K2317/24

    摘要： Described are novel chimeric anti-human immunodeficiency virus (HIV) antibodies which comprise a constant region derived from human antibody and variable region derived from mouse monoclonal antibody, gene fragments coding for the variable region the H and L chain of chimeric anti-HIV antibodies which are effective for expression of chimeric anti-HIV antibodies having an HIV-neutralizing activity, a transformant where such gene fragments are incorporated, chimeric anti-HIV antibodies expressed therefrom and a process for their preparation. The chimeric anti-HIV antibodies of the present invention show anti-HIV neutralizing activity and are useful for the diagnosis, treatment and prevention of acquired immunodeficiency syndrome (AIDS) caused by HIV without side effects such as anaphylactic shock or serum sickness.

    摘要翻译： 描述的是新颖的，其包括来自人抗体和小鼠单克隆抗体的可变区的恒定区的嵌合抗 - 人免疫缺陷病毒（HIV）抗体，基因片段编码嵌合抗-HIV抗体的H和L链的可变区，其 有效用于具有HIV中和活性，其中一个检查基因片段掺入转化体，从那里过表达嵌合抗HIV抗体和用于制备它们的方法的嵌合抗-HIV抗体的表达。 本发明显示抗HIV中和活性的和嵌合的抗HIV抗体可用于无副作用由HIV引起的诊断，治疗和预防获得性免疫缺陷综合症的（AIDS）有用：如过敏性休克或血清病。