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    Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulins
    8.
    发明公开
    Dog-mouse heterohybridoma and gene fragment coding for constant region of canine immunoglobulins 失效
    Hund-Maus-Heterohybridoma undfürdie konstante Region von Hunde-Immunglobulinen kodierendes Genfragment。

    公开(公告)号：EP0419858A1

    公开(公告)日：1991-04-03

    申请号：EP90116258.6

    申请日：1990-08-24

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Ono, Yoichi ,  Tokiyoshi, Sachio

    IPC分类号： C12N15/13 ,  C07K16/46 ,  C12N5/26

    CPC分类号： C07K16/462 ,  A61K39/00 ,  C07K2317/24

    摘要： A gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine im­munoglobulin lambda chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of canine immunoglobulin kappa chain; a gene fragment which com­prises a DNA sequence coding for the constant region of canine immunoglobulin gamma chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-dog chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a canine immunoglobulin wherein the latter gene fragment; a polypeptide of a mouse-dog chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule cording for an amino acid sequence of the mouse-dog chimeric antibody is incorporated; a dog-mouse heterohybridoma which produces canine immunoglobulin; and a process for preparing a canine im­munoglobulin gene.

    摘要翻译： 一种基因片段，其包含编码犬免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 包含编码犬免疫球蛋白κ链恒定区氨基酸序列的DNA序列的基因片段; 一种基因片段，其包含编码犬免疫球蛋白γ链恒定区的DNA序列; 编码小鼠 - 狗嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段 的犬免疫球蛋白，其中后者基因片段; 从用细胞表达载体转化的细胞中表达小鼠 - 狗嵌合抗体的多肽，其中并入所述针对小鼠 - 狗嵌合抗体的氨基酸序列的重组DNA分子; 产生犬免疫球蛋白的狗 - 小鼠异源杂交瘤; 以及制备犬免疫球蛋白基因的方法。

    Method for the measurement of TSH
    9.
    发明公开
    Method for the measurement of TSH 失效
    Verfahren zum Messen von TSH。

    公开(公告)号：EP0212522A2

    公开(公告)日：1987-03-04

    申请号：EP86111064.1

    申请日：1986-08-11

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Nakashima, Toshihiro ,  Unoki, Masanori ,  Eda, Yasuyuki ,  Fujita, Haruo

    IPC分类号： G01N33/74

    CPC分类号： G01N33/76 ,  G01N33/74

    摘要： Described is an improved method for the measurement of TSH in blood or body liquid by immunoassays such as EIA and RIA, characterized in that TSH-P subunit specific monoclonal antibodies recognizing different epitopes are used. According to this method, TSH can easily be measured in high sensitivity with high specificity within a very short period of time without inhibition by the presence of other glycoprotein hormones such as LH, HCG and FSH. This method is useful for diagnosis of various diseases in which TSH plays a role, such as proto- phathic hypothyroidism, Basedow's disease and cretinism.

    摘要翻译： 描述了通过免疫测定如EIA和RIA测量血液或体液中的TSH的改进方法，其特征在于使用识别不同表位的TSH-β亚基特异性单克隆抗体。 根据该方法，可以在非常短的时间内容易地以高特异性的高灵敏度测定TSH，而不会抑制其它糖蛋白激素如LH，HCG和FSH的抑制。 这种方法可用于诊断TSH发挥作用的各种疾病，如原发性甲状腺功能减退症，基诺病和克氏病。

    Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma
    10.
    发明公开
    Cat-mouse chimeric antibody directed to feline diseases and corresponding heterohydridoma 失效
    Gegen Katze-Krankheite chimaerischer Katze-Maus-Antikörper和杂交杂交瘤

    公开(公告)号：EP1156064A2

    公开(公告)日：2001-11-21

    申请号：EP01118802.6

    申请日：1990-08-10

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Maeda, Hiroaki ,  Eda, Yasuyuki ,  Kimachi, Kazuhiko ,  Ono, Yoichi, Shinki Appartment 101 ,  Tokiyoshi, Sachio

    IPC分类号： C07K16/46 ,  C12N15/13 ,  C12N5/20 ,  G01N33/50

    CPC分类号： C12N5/166 ,  C07K16/00 ,  C07K16/081 ,  C07K16/462 ,  C07K2317/24 ,  C07K2319/00

    摘要： The application discloses a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin λ chain; a gene fragment which comprises a DNA sequence coding for an amino acid sequence of a constant region of feline immunoglobulin κ chain; a gene fragment which comprises a DNA sequence coding for the constant region of feline immunoglobulin γ chain; a recombinant DNA molecule coding for an amino acid sequence of a mouse-cat chimeric antibody which comprises a gene fragment coding for an amino acid sequence of a variable region of a mouse immunoglobulin and a gene fragment coding for an amino acid sequence of a constant region of a feline immunoglobulin wherein the latter gene fragment is linked to the 3' site of the former gene fragment; a polypeptide of a mouse-cat chimeric antibody which is expressed from a cell transformed with an expression vector for cells wherein said recombinant DNA molecule coding for an amino acid sequence of the mouse-cat chimeric antibody is incorporated; a cat-mouse heterohybridoma which produces feline immunoglobulin; and a process for preparing a feline immunoglobulin gene.

    摘要翻译： 该申请公开了一种基因片段，其包含编码猫免疫球蛋白λ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白κ链的恒定区的氨基酸序列的DNA序列; 一种基因片段，其包含编码猫免疫球蛋白γ链恒定区的DNA序列; 编码小鼠-cat嵌合抗体的氨基酸序列的重组DNA分子，其包含编码小鼠免疫球蛋白的可变区的氨基酸序列的基因片段和编码恒定区的氨基酸序列的基因片段 的猫免疫球蛋白，其中后一个基因片段连接到前一个基因片段的3'位点; 一种小鼠-cat嵌合抗体的多肽，其由转化有细胞表达载体的细胞表达，其中所述重组DNA分子编码小鼠-cat嵌合抗体的氨基酸序列; 产生猫免疫球蛋白的猫 - 鼠异种杂交瘤; 以及制备猫免疫球蛋白基因的方法。