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公开(公告)号：EP0140386A3
公开(公告)日：1987-03-04
申请号：EP84113134
申请日：1984-10-31
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/822
摘要： Described is a method for producing highly pure LPF-HA (Leucocytosis-promoting Factor Hemagglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this invention is highly pure and contains almost no endotoxin of B. pertussis and is useful for the preparation of various reagents utilizing the physiological activities, of a medicine for treating diabetes and of a pertussis vaccine.
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公开(公告)号：EP0140386B1
公开(公告)日：1990-10-03
申请号：EP84113134.5
申请日：1984-10-31
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/822
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公开(公告)号：EP0140386A2
公开(公告)日：1985-05-08
申请号：EP84113134.5
申请日：1984-10-31
CPC分类号： C07K14/235 , A61K39/00 , Y10S435/822
摘要： Described is a method for producing highly pure LPF-HA (Leucocytosis-promoting Factor Hemagglutinin) from culture media of Bordetella pertussis in a high yield by an affinity chromatography using a denatured ceruloplasmin as a ligand. The LPF-HA obtained by this invention is highly pure and contains almost no endotoxin of B. pertussis and is useful for the preparation of various reagents utilizing the physiological activities, of a medicine for treating diabetes and of a pertussis vaccine.
摘要翻译： 描述了通过使用变性的血浆铜蓝蛋白作为配体的亲和层析以高产率从培养的百日咳杆菌培养基生产高纯度LPF-HA（白细胞增多促血糖因子血凝素）的方法。 通过本发明获得的LPF-HA是高纯度的，并且几乎不含有百日咳杆菌的内毒素，并且可用于制备利用生理活性的各种试剂，用于治疗糖尿病的药物和百日咳疫苗。
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