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    ADENYLATE CYCLASE TOXOID WITH REDUCED CYTOLYTIC ACTIVITY
    1.
    发明公开
    ADENYLATE CYCLASE TOXOID WITH REDUCED CYTOLYTIC ACTIVITY 审中-公开

    公开(公告)号：EP3381931A1

    公开(公告)日：2018-10-03

    申请号：EP17163566.7

    申请日：2017-03-29

    申请人： Mikrobiologicky ustav AV CR, v.v.i.

    发明人： Masin, Jiri ,  Osicka, Radim ,  Sebo, Peter ,  Osickova, Adriana

    IPC分类号： C07K14/235 ,  A61K39/02

    CPC分类号： C07K14/235 ,  A61K39/099

    摘要： The present invention provides a polypeptide antigen comprising amino acid sequence of adenylate cyclase protein of Bordetella pertussis bearing the following mutations:
    (i) substitution of the alanine residue in position 680 by a proline residue, and
    (ii) substitution of the valine residue in position 695 by a proline residue,
    or one or more fragments thereof, wherein said fragments comprise at least amino acids from position 374 to position 400, from position 500 to position 700, and from position 860 to position 1706.
    Said polypeptide antigen is suitable for use in a method of treatment and/or prevention of a disease caused by Bordetella pertussis, in particular against pertussis or whooping cough disease.
    The invention further provides a chimeric protein, a polynucleotide encoding the polypeptide antigen or chimeric protein, a vector and a host cell for the production of said polypeptide or protein.

    MUCOSAL ADJUVANT COMPOSITION
    5.
    发明公开
    MUCOSAL ADJUVANT COMPOSITION 审中-公开
    SCHLEIMHAUTADJUVANTIENZUSAMMENSETZUNG

    公开(公告)号：EP2623118A4

    公开(公告)日：2014-05-07

    申请号：EP11828423

    申请日：2011-09-27

    申请人： KYORITSU SEIYAKU CORP

    发明人： ASAI KEN-ICHI ,  KAWAKAMI KAZUO ,  MOCHIZUKI MASAMI

    IPC分类号： C07K14/235 ,  A61K39/39 ,  A61P31/12 ,  A61P31/16

    CPC分类号： A61K39/39 ,  A61K38/162 ,  A61K39/099 ,  A61K39/12 ,  A61K2039/52 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55594 ,  C07K14/235 ,  C12N2710/10034 ,  C12N2760/18034

    摘要： [Problem to be Solved] The present invention provides a novel mucosal adjuvant. [Solution] The present invention provides a mucosal adjuvant composition containing at least a composition comprising molecules having a molecular weight in a range of 100 to 300 kDa obtained from cells or culture fluid of Bordetella bronchiseptica. Administration of the mucosal adjuvant composition to a non-human animal and the like at a surface of mucous membrane can enhance immunity at the surface of mucous membrane. Therefore, for example, preventive effects against trans-mucosal infection can be increased by administering an inactivated vaccine against trans-mucosal infection and the mucosal adjuvant composition to a non-human animal at a surface of mucous membrane. The present invention is effective for preventing trans-mucosal infections, including one or more infections of, for example, canine parainfluenza, canine adenovirus, canine coronavirus, canine parvovirus, canine distemper virus, canine herpesvirus, reovirus and pneumovirus.

    Novel recombinant Bordetella strains
    6.
    发明公开
    Novel recombinant Bordetella strains 审中-公开
    Neue rekombinante Bordetella-Stämme

    公开(公告)号：EP2722338A1

    公开(公告)日：2014-04-23

    申请号：EP12306279.6

    申请日：2012-10-17

    申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  INSTITUT PASTEUR DE LILLE

    发明人： Locht, Camille ,  Mielcarek, Nathalie

    IPC分类号： C07K14/235 ,  C12N1/36

    CPC分类号： C12N1/36 ,  A61K39/092 ,  A61K39/099 ,  A61K39/12 ,  A61K2039/522 ,  A61K2039/523 ,  A61K2039/543 ,  C07K14/235 ,  C12N2760/16134 ,  C12N2760/18534

    摘要： The present invention relates to a recombinant genetically attenuated Bordetella strain expressing a hybrid protein comprising the N-terminal fragment of filamentous haemagglutinin (FHA) and a heterologous epitope or antigenic protein or protein fragment, different from FHA, wherein the gene coding for the native FHA protein is inactivated.
    The Bordetella strain is preferably a Bordetella pertussis strain, but may also be another Bordetella species, such as Bordetella bronchiseptica, Bordetella parapertussis or Bordetella avium.
    The invention further provides a life attenuated vaccine for the treatment of a mucosal or systemic infectious disease comprising a Bordetella strain as defined above intended to elicit a immune response against pathogens responsible for systemic or mucosal infections, including of the upper or lower respiratory tract.
    The present invention also relates to a method for prophylaxis of an infectious disease in a mammal, comprising administering to said mammal an effective amount of a vaccine comprising in a suitable vehicle a recombinant attenuated Bordetella strain expressing a fusion protein comprising the N-terminal fragment of filamentous haemagglutinin (FHA) and a heterologous epitome or antigenic protein or protein fragment, different from FHA, wherein the gene coding for the native FHA protein is inactivated.

    摘要翻译： 本发明涉及表达包含丝状血凝素（FHA）的N末端片段和不同于FHA的异源表位或抗原蛋白或蛋白质片段的杂交蛋白质的重组遗传减毒博德氏菌属菌株，其中编码天然FHA的基因 蛋白质被灭活。 博德氏菌属菌株优选是百日咳杆菌菌株，但也可以是另一种博德氏菌属物种，例如支气管炎博德特氏菌，百日咳杆菌或博德特氏菌。 本发明进一步提供了一种用于治疗粘膜或全身性感染性疾病的减毒活疫苗，其包含如上所定义的博德特氏菌属菌株，以引起针对包括上呼吸道或下呼吸道系统或粘膜感染的病原体的免疫应答。 本发明还涉及一种用于预防哺乳动物感染性疾病的方法，包括向所述哺乳动物施用有效量的疫苗，其在合适的载体中包含表达融合蛋白的重组减毒博德特菌属菌株，所述融合蛋白包含N末端片段 丝状血凝素（FHA）和与FHA不同的异源成像或抗原蛋白或蛋白质片段，其中编码天然FHA蛋白的基因被灭活。

    New malonate decarboxylases for industrial applications
    9.
    发明公开
    New malonate decarboxylases for industrial applications 审中-公开
    Neue Malonatdekarboxylsenfürindustrielle Anwendungen

    公开(公告)号：EP2065470A1

    公开(公告)日：2009-06-03

    申请号：EP07023075.0

    申请日：2007-11-28

    申请人： BASF SE

    发明人： The designation of the inventor has not yet been filed

    IPC分类号： C12P7/40 ,  C12P7/42 ,  C12N9/88 ,  C12N9/90 ,  C12N15/61 ,  C12Q1/00

    CPC分类号： C12N9/88 ,  C07K14/235 ,  C07K2299/00 ,  C12N9/90 ,  C12P7/40 ,  C12P7/42 ,  C12Q1/00 ,  C12Y401/01075 ,  C12Y401/01076

    摘要： The present invention relates to a method for the enzymatic decarboxylation of aryl-substituted malonic acid (propanedioic acid) derivatives catalyzed by enzymes structurally and/or functionally related to arylmalonate decarboxylase (AMDase) as isolated from microorganisms of the genus Bordetella. The present invention also relates to novel enzymes with arylmalonate decarboxylase activity, useful for performing the claimed method, mutants thereof, corresponding coding sequences and expression systems, methods of preparing said novel enzymes, and screening methods for obtaining further suitable enzymes also having said arylmalonate decarboxylase activity.

    摘要翻译： 本发明涉及一种由结构和/或与芳基丙二酸脱羧酶（AMDase）结合和/或功能相关的由博德特氏菌属微生物分离的酶催化的芳基取代的丙二酸（丙二酸）衍生物的酶脱羧的方法。 本发明还涉及具有芳基丙二酸酯脱羧酶活性的新型酶，可用于进行所要求保护的方法，其突变体，相应的编码序列和表达系统，制备所述新型酶的方法，以及筛选获得还具有所述芳基丙二酸脱羧酶的合适酶的筛选方法 活动。