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1.发明公开
公开(公告)号：EP2243829A1
公开(公告)日：2010-10-27
申请号：EP09700904.7
申请日：2009-01-09
发明人： UEHARA, Kenji , HIGUCHI, Hirofumi , NAKASHIMA, Toshihiro , ISHIKAWA, Daisuke , YAMAMOTO, Nobuchika , FUJITA, Hirotada , SAKAI, Fumihiko
IPC分类号： C12N15/00 , A61K39/395 , A61P29/00 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to a donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:11 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:13 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:17, a humanized anti-human α9 integrin antibody containing a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:15 and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO:9, and a means for the prophylaxis or treatment of various diseases involving human α9 integrin in the pathogenesis, which uses the antibody.
摘要翻译： 本发明提供与供体小鼠抗人±9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人±9整联蛋白抗体，即含有重链的人源化抗人±9整联蛋白抗体 由SEQ ID NO：11所示的氨基酸序列组成的可变区和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含重链的人源化抗人±9整联蛋白抗体 由SEQ ID NO：13所示的氨基酸序列组成的可变区和由SEQ ID NO：17所示的氨基酸序列组成的轻链可变区，包含重链的人源化抗人±9整联蛋白抗体 由SEQ ID NO：15所示的氨基酸序列组成的可变区和由SEQ ID NO：9所示的氨基酸序列组成的轻链可变区，以及预防或治疗涉及人类± 9整数 rin在发病机制中，其使用抗体。
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公开(公告)号：EP2239323A1
公开(公告)日：2010-10-13
申请号：EP09700866.8
申请日：2009-01-09
发明人： UEHARA, Kenji , HIGUCHI, Hirofumi , NAKASHIMA, Toshihiro , ISHIKAWA, Daisuke , YAMAMOTO, Nobuchika , FUJITA, Hirotada , SAKAI, Fumihiko
IPC分类号： C12N15/00 , A61K39/395 , A61P29/00 , C07K16/28 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/08
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides a humanized anti-human α9 integrin antibody having improved activity and/or property as compared to donor mouse anti-human α9 integrin antibody, namely, a humanized anti-human α9 integrin antibody comprising a heavy-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 1 or the amino acid sequence shown by SEQ ID NO: 1 wherein one or several amino acids are substituted, deleted, inserted and/or added and a light-chain variable region consisting of the amino acid sequence shown by SEQ ID NO: 61 or the amino acid sequence shown by SEQ ID NO: 61 wherein one or several amino acids are substituted, deleted, inserted and/or added, as well as a means for preventing or treating various diseases involving human α9 integrin in their pathogenesis, which uses the antibody.
摘要翻译： 本发明提供与供体小鼠抗人±9整联蛋白抗体相比具有改善的活性和/或性质的人源化抗人±9整联蛋白抗体，即包含重链变量的人源化抗人±9整联蛋白抗体 由SEQ ID NO：1所示的氨基酸序列或SEQ ID NO：1所示的氨基酸序列组成的区域，其中一个或几个氨基酸被取代，缺失，插入和/或加入，以及轻链可变区 的SEQ ID NO：61所示的氨基酸序列或SEQ ID NO：61所示的氨基酸序列，其中一个或几个氨基酸被取代，缺失，插入和/或添加，以及用于预防或治疗的手段 各种疾病涉及人类±9整联蛋白在其发病机理中，其使用抗体。
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公开(公告)号：EP2236605A1
公开(公告)日：2010-10-06
申请号：EP08867627.5
申请日：2008-12-26
发明人： TORIKAI, Masaharu , ISHIKAWA, Daisuke , NAKASHIMA, Toshihiro , HIGUCHI, Hirofumi , SAKAI, Fumihiko , YAMAMOTO, Nobuchika , FUJITA, Hirotada , TAGUCHI, Katsunari
IPC分类号： C12N15/09 , A61K39/395 , A61P11/00 , A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P37/06 , A61P37/08 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： C07K16/2839 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/622 , C07K2317/92 , C07K2319/00
摘要： The present invention provides a human anti-α9 integrin antibody or an antibody fragment which specifically recognize human α9 integrin and mouse α9 integrin, inhibit interaction with their ligands, particularly, the antibody or antibody fragment which recognize loop regions of human and mouse α9 integrins, a gene encoring the antibody or antibody fragment, a recombinant expression vector containing the gene, a transformant harboring the gene, production method of human anti-α9 integrin antibody or antibody fragment using the transformant, and an agent for the prophylaxis or treatment of rheumatoid arthritis which contains the antibody or antibody fragment.
摘要翻译： 本发明提供一种人抗±9整联蛋白抗体或特异性识别人±9整联蛋白和小鼠±9整联蛋白的抗体片段，抑制与其配体的相互作用，特别是识别人和小鼠环区的抗体或抗体片段 ±9整合素，携带抗体或抗体片段的基因，含有该基因的重组表达载体，携带该基因的转化体，使用该转化体的人抗±9整联蛋白抗体或抗体片段的制备方法以及预防剂 或治疗包含抗体或抗体片段的类风湿性关节炎。
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公开(公告)号：EP3299461A1
公开(公告)日：2018-03-28
申请号：EP16799968.9
申请日：2016-05-20
申请人： Astellas Pharma Inc.
IPC分类号： C12N15/09 , A61K39/395 , A61P25/04 , A61P29/00 , C07K16/22 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/08
CPC分类号： A61K39/39533 , A61K2039/505 , A61P25/04 , A61P29/00 , C07K16/22 , C07K2317/40 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10 , C12N15/09
摘要： To provide a superior anti-human NGF antibody Fab fragment that maintains a high neutralizing activity, and that reduces systemic side-effects arising from systemic exposure while expressing a local drug effect, and means for treating postoperative pain by using such antibody fragment.
An anti-human NGF antibody Fab fragment comprising a heavy-chain fragment consisting of the amino acid sequence shown by SEQ ID NO:5 and a light-chain consisting of the amino acid sequence shown by SEQ ID NO: 8.摘要翻译： 为了提供一种优异的抗人NGF抗体Fab片段，其保持高度中和活性，并且在表达局部药物作用的同时降低由全身暴露引起的全身性副作用，以及通过使用此类抗体片段来治疗手术后疼痛的手段。 包含由SEQ ID NO：5所示的氨基酸序列组成的重链片段和由SEQ ID NO：8所示的氨基酸序列组成的轻链的抗人NGF抗体Fab片段。
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公开(公告)号：EP2243829B1
公开(公告)日：2014-08-20
申请号：EP09700904.7
申请日：2009-01-09
申请人： Astellas Pharma Inc.
发明人： UEHARA, Kenji , HIGUCHI, Hirofumi , NAKASHIMA, Toshihiro , ISHIKAWA, Daisuke , YAMAMOTO, Nobuchika , FUJITA, Hirotada , SAKAI, Fumihiko
IPC分类号： A61K39/395 , A61P29/00 , C07K16/28 , C07K16/46
CPC分类号： C07K16/2839 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94
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