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公开(公告)号：EP4435109A1
公开(公告)日：2024-09-25
申请号：EP22895653.8
申请日：2022-11-16
申请人： Tokyo University of Pharmacy and Life Science , National University Corporation Tottori University
发明人： TOMIZUKA, Kazuma , UNO, Narumi , KAZUKI, Yasuhiro
IPC分类号： C12N15/85 , A01K67/027 , C12N5/10 , C12P21/00
CPC分类号： A01K67/027 , C12P21/00 , C12N15/85 , C12N5/10
摘要： An object of the present invention is to provide a promoter activation sequence that allows for stable and efficient expression of a DNA of interest in a mammalian cell. The present invention provides a promoter activation sequence comprising a nucleotide sequence represented by SEQ ID NO: 1, or a nucleotide sequence of 850 or more in a nucleotide sequence having 85% or higher sequence identity thereto; an expression vector comprising the promoter activation sequence, a promoter, and a DNA of interest; and a mammalian cell or a mammal comprising the expression vector.
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公开(公告)号：EP4421092A1
公开(公告)日：2024-08-28
申请号：EP22882219.3
申请日：2022-03-21
发明人： HUANG, Yingfeng , LANG, Guojun , TAN, Yongcong , SHAO, Zhe , ZHANG, Ruixia , YAN, Run , WANG, Tao , XU, Junyan , HU, Yuhao , ZHANG, Wenhai
CPC分类号： A61K39/395 , A61K47/68 , A61P35/00 , C07K16/00 , C07K16/28 , C07K16/46 , C12N5/10 , C12N15/70 , C12N15/74 , C12N15/85 , C12P19/34 , C12R2001/1920210501
摘要： The present invention belongs to the field of biomedicine. Specifically, the present invention relates to an anti-CD47/anti-CLDN18.2 bispecific antibody and the use thereof.
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公开(公告)号：EP4410971A1
公开(公告)日：2024-08-07
申请号：EP22876533.5
申请日：2022-09-30
申请人： FUJIFILM Corporation
发明人： MORI Yusuke , UMETANI Sayako , MURAGUCHI Taichi
IPC分类号： C12N7/01 , C12N5/10 , C12N15/86 , C12N15/864
CPC分类号： C12N15/864 , C12N5/10 , C12N15/86 , C12N7/00
摘要： An object of the present invention is to provide a manufacturing method of an adeno-associated virus, which can improve a production amount of the adeno-associated virus, and to provide a cell and an expression vector for use in the manufacturing method of an adeno-associated virus. According to the present invention, provided is a manufacturing method of an adeno-associated virus, including expressing an E4ORF6 gene with an exogenous promoter, in which expression of E4ORF6 is reduced as compared with a case where E4ORF6 is expressed using an expression unit containing an enhancer, a cytomegalovirus-derived promoter, a Kozak sequence, an E4ORF6 gene, and a polyA signal sequence.
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公开(公告)号：EP4410963A1
公开(公告)日：2024-08-07
申请号：EP22876262.1
申请日：2022-09-27
申请人： Sumitomo Chemical Company, Limited , Sumitomo Pharma Co., Ltd. , National University Corporation Tokai National Higher Education and Research System
摘要： The present invention aims to provide a method for efficiently producing a cell population containing pituitary tissue from pluripotent stem cells. The method for producing a cell population containing pituitary tissue includes the following steps (1) and (2):
(1) a first step of culturing the pluripotent stem cells in the presence of a c-jun N-terminal kinase (JNK) signal transduction pathway inhibiting substance and a Wnt signal transduction pathway inhibiting substance,
(2) a second step of culturing the cell population obtained in the first step in the presence of a BMP signal transduction pathway activating substance and a Sonic hedgehog signal transduction pathway activating substance, thereby obtaining a cell population containing pituitary tissue.-
公开(公告)号：EP4400591A1
公开(公告)日：2024-07-17
申请号：EP22867792.8
申请日：2022-09-06
发明人： KONONOV, Aleksey Vladimirovich , ZHIRIAKOVA, Mariia Vladimirovna , GORDEEV, Aleksandr Andreevich , PUCHKOVA, Mariia Yurievna , SOLOVYEV, Valery Vladimirovich , MOROZOV, Dmitry Valentinovich
IPC分类号： C12N15/63 , C12N5/10 , C12Q1/6897 , G01N33/533
CPC分类号： C12Q1/6897 , G01N33/533 , C12N15/63 , C12N5/10
摘要： The present invention relates to the fields of biotechnology and molecular biology, in particular to a universal inducible promoter, vector and host cell based thereon, as well as to a method for producing said host cell. The proposed inventions make it possible to analyze the activity of a target protein, for example, a receptor ligand, for example, a cytokine.
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公开(公告)号：EP4400589A1
公开(公告)日：2024-07-17
申请号：EP22867379.4
申请日：2022-09-07
发明人： ODAKA, Rei , SANO, Ryoko , IWASAKI, Takumi , BABA, Masahiro , SABURI, Wataru , MORI, Haruhide
IPC分类号： C12N15/56 , A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/38 , C12N15/63
CPC分类号： A23C7/04 , A23C9/12 , A23C21/02 , A23C23/00 , A23L33/00 , C12N5/10 , C12N9/24 , C12N9/2468 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/74
摘要： Provided is a lactase preparation having an excellent lactose decomposing action in milk. A lactase according to an aspect of the present invention has, as lactase activity, any one of the following activities (1) to (6) or a combination of two or more thereof:
(1) when the lactase is added to cow's milk, an added amount of protein in the lactase at which a residual lactose concentration reaches 0.1% or less after 16 hours at 10°C is 15.1 mg/L or less;
(2) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 16 hours at 10°C is 30.2 mg/L or less;
(3) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.1% or less after 24 hours at 10°C is 10.1 mg/L or less;
(4) when the lactase is added to cow's milk, the added amount of protein in the lactase at which the residual lactose concentration reaches 0.01% or less after 24 hours at 10°C is 15.1 mg/L or less;
(5) when the lactase is added to cow's milk in an amount that makes a final concentration 1.4 LYU/ml, the residual lactose concentration reaches 0.1% or less after 24 hours at 10°C; and
(6) when the lactase is added to cow's milk in the amount that makes a final concentration 2.1 LYU/ml, the residual lactose concentration reaches 0.01% or less after 24 hours at 10°C.-
公开(公告)号：EP4400587A1
公开(公告)日：2024-07-17
申请号：EP22867164.0
申请日：2022-08-19
IPC分类号： C12N15/54 , B60C1/00 , C08K3/00 , C08K5/00 , C08L21/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N11/02 , C12N15/63 , C12P5/02
CPC分类号： B60C1/00 , C08K3/00 , C08K5/00 , C08L21/00 , C12N5/10 , C12N9/10 , C12N11/02 , C12N15/63 , C12N15/80 , C12N15/81 , C12N15/74 , C12P5/02
摘要： The present invention aims to provide a method for producing a trans-polyisoprenoid (trans-1,4-polyisoprene) with a molecular weight of more than 105 in an enzymatic manner. The present invention relates to a method for producing a trans-polyisoprenoid, which includes binding to a lipid membrane in vitro a trans-prenyltransferase (tPT) family protein capable of producing a product with a molecular weight of 104 or more when not bound to any lipid membrane.
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公开(公告)号：EP4394033A1
公开(公告)日：2024-07-03
申请号：EP22860553.1
申请日：2022-08-24
发明人： LI, Linhong , ZHU, Xiangyang , LIU, Wuqing , YU, Shijun , XIN, Pengcheng , WANG, Li , YANG, Xingxing , ZHAN, Yifan , WEI, Xiaoyue
IPC分类号： C12N5/10 , C12N15/113 , C12N15/62 , A61K39/00 , A61P35/00
CPC分类号： C12N15/113 , A61P35/00 , C12N15/62 , C12N5/10 , A61K39/4631 , A61K39/4611 , A61K2239/5320230501 , A61K39/4644
摘要： Provided are a T cell product for administration to a subject and a use thereof. The product comprises at least one allogeneic T cell, the allogeneic T cell expressing at least one MHC molecule identified as an exogenous source by at least one T cell of the subject. The T cell product can widen the range of a donor and activate an immune response of the subject. Further provided is a use of the T cell product in the preparation of a drug for treating tumors.
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公开(公告)号：EP4382612A1
公开(公告)日：2024-06-12
申请号：EP22853209.9
申请日：2022-08-08
申请人： AJINOMOTO CO., INC.
CPC分类号： C07K14/435 , C07K14/705 , C12N5/10 , C12Q1/02 , G01N33/02 , G01N33/50
摘要： A method for measuring a response of an olfactory receptor to a substance is provided. The test substance and the olfactory receptor are contacted under such a condition that response of adenosine receptor to the test substance is reduced, and response of the olfactory receptor to the test substance is measured.
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