公开(公告)号：EP2647391A4

公开(公告)日：2016-07-06

申请号：EP11845744

申请日：2011-09-29

申请人： KANEKA CORP

发明人： TAGO YOSHIYUKI ,  YOSHIDA SHINICHI ,  OHNO KOHJI ,  TSUJII YOSHINOBU ,  TABATA YASUHIKO

IPC分类号： A61K49/00 ,  A61K49/18

CPC分类号： A61K49/12 ,  A61K49/1854 ,  A61K49/186

摘要： Intended is to provide an MRI contrast agent that tends not to be phagocytized by reticuloendothelial cells and that has improved dispersion stability. The present invention is an MRI contrast agent containing composite particles, wherein the composite particles are those with polymer graft chains bound to surfaces of microparticles at a very high density sufficient to allow steric repulsion to occur between the graft chains, the microparticles are inorganic microparticles that exhibit superparamagnetism, and the polymer graft chains have a number average molecular weight (Mn) of at least 30,000. Preferably, the MRI contrast agent is for tumor diagnosis.