公开(公告)号：EP3363467A1

公开(公告)日：2018-08-22

申请号：EP17205645.9

申请日：2017-12-06

申请人： Jacobson Research Laboratory Limited

发明人： KWOK, Connie Sau-Kuen ,  CHENG, Kwok Kin

IPC分类号： A61K49/18

CPC分类号： A61K49/1854 ,  A61K49/186 ,  A61K49/1881

摘要： The present invention relates to a composition for use as a contrast agent in medical imaging. The composition comprises a metal ion containing compound comprises at least one metal ion adapted to bind with one or more metal ion chelating agents; wherein said one or more metal ion chelating agents comprise at least one first chelating agent adapted to target a region of interest being imaged, and at least one second chelating agent having at least one functional group adapted to dissociate in an aqueous medium to thereby allow or enhance contrast of the region of interest under the medical imaging. The present invention further relates to a diagnostic agent for use in amyloid (Aβ) protein detection under magnetic resonance imaging (MRI) comprising the above described composition; and a method of preparing thereof.

公开(公告)号：EP2502882A4

公开(公告)日：2016-01-20

申请号：EP10831610

申请日：2010-11-18

申请人： TODA KOGYO CORP

发明人： HAKATA TOSHIYUKI ,  OKITA TOMOKO

IPC分类号： C01G49/00 ,  A61K9/10 ,  A61K47/02 ,  A61K49/00 ,  A61K49/04 ,  C01G49/08 ,  C09C1/24

CPC分类号： C09C1/24 ,  A61K41/0052 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0002 ,  A61K49/0428 ,  A61K49/1854 ,  B82Y5/00 ,  B82Y30/00 ,  C01G49/0036 ,  C01G49/08 ,  C01P2004/64 ,  C01P2004/80 ,  C01P2006/12 ,  C01P2006/42

摘要： The present invention relates to a magnetic particle-containing water dispersion wherein the magnetic particles have a primary particle diameter of 5 to 15 nm and an average secondary particle diameter of 10 to 60 nm, and the water dispersion has a zeta potential of not more than -20 mV when a pH value of the water dispersion lies within the range of 6 to 8, and further a surface of the respective magnetic particles is coated with a carboxyl group-containing polymer. The magnetic particle-containing water dispersion is produced by heating an aqueous solution in which the carboxyl group-containing polymer is dissolved, to a temperature of 90 to 100°C in a nitrogen atmosphere; adding a solution of a ferrous (II) salt and a ferric (III) salt and an alkali solution to the aqueous solution to react with each other at the same temperature; adding ethanol to the solution to obtain a precipitate; and removing a supernatant liquid from the solution, and then dispersing the precipitate in water and subjecting the resulting dispersion to dialysis. The magnetic particle-containing water dispersion is useful as a magnetic particle-containing water dispersion capable of producing magnetic particle-containing drugs for diagnosis and therapies which can exhibit a uniform functionality, with a good reproducibility.

公开(公告)号：EP2481710A4

公开(公告)日：2015-07-22

申请号：EP10826341

申请日：2010-10-28

申请人： TOKYO INST TECH

发明人： HANDA HIROSHI ,  HATAKEYAMA MAMORU ,  SAKAMOTO SATOSHI ,  KISHI HIROSHI

IPC分类号： C01G49/06 ,  A61K9/50 ,  A61K41/00 ,  A61K47/02 ,  A61K49/18 ,  C01G49/00 ,  C01G49/08 ,  C09C1/22 ,  C09C1/24 ,  H01F1/00 ,  H01F1/34

CPC分类号： A61K41/0052 ,  A61K9/5026 ,  A61K9/5089 ,  A61K9/5094 ,  A61K47/02 ,  A61K49/1854 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  C01G49/0072 ,  C01G49/08 ,  C01P2004/03 ,  C01P2004/64 ,  C09C1/22 ,  C09C1/24 ,  H01F1/0054 ,  H01F1/344

摘要： [Object] To provide a polymer coated ferrite fine particles being possible to control a particle size uniformly while having high aqueous dispersibility and preferred biomolecule immobilization ability and an easy method for preparing the same. [Means Addressing Object] In an aqueous solvent, iron ion is protected by chelating polyacrylic acid and then alkaline is added. Thereafter, a reaction system is heated under pressurized condition to produce simultaneous precipitation of the ferrite fine particles and coating thereof. As the result, the polymer coated ferrite fine particles having uniform particle size may be prepared in one step with excellent reproducibility. The polymer coated ferrite fine particles of the present invention has high water dispersibility and has preferred biomolecule immobilization performance by carboxyl groups coming from the polyacrylic acid.

摘要翻译： 本发明提供可以均匀地控制粒径的聚合物涂覆的铁氧体细颗粒，同时具有高的水分散性和优选的生物分子固定能力以及其制备方法。 [装置寻址对象]在水性溶剂中，铁离子被螯合聚丙烯酸保护，然后加入碱。 此后，在加压条件下加热反应体系，以产生铁素体微粒及其涂层的同时析出。 结果，可以在一个步骤中制备具有均匀粒径的聚合物涂覆的铁氧体细颗粒，具有优异的再现性。 本发明的聚合物涂覆的铁素体微粒具有高的水分散性，并且具有优选的生物分子固定性能，其来自聚丙烯酸的羧基。

公开(公告)号：EP1996508A4

公开(公告)日：2010-12-22

申请号：EP07715412

申请日：2007-02-27

申请人： IND ACADEMIC COOP

发明人： CHEON JIN WOO ,  JUN YOUNG WOOK ,  CHOI JIN SIL

IPC分类号： B82B3/00 ,  A23L3/358 ,  A61F2/14 ,  A61K41/00 ,  A61K47/48 ,  A61L2/238 ,  A61L27/04

CPC分类号： A61K41/0042 ,  A61K41/0052 ,  A61K49/1833 ,  A61K49/1836 ,  A61K49/1854 ,  A61K49/1857 ,  A61K49/186 ,  A61K49/1863 ,  A61K49/1866 ,  A61K49/1869 ,  A61K49/1875 ,  A61L2/238 ,  A61L27/50 ,  A61L2400/12 ,  A61L2400/18 ,  B82Y5/00 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T436/143333

公开(公告)号：EP1885721B1

公开(公告)日：2009-07-29

申请号：EP06725304.7

申请日：2006-03-24

申请人： GUERBET

发明人： PORT, Marc

IPC分类号： C07D471/04 ,  C07F15/00 ,  A61K49/06 ,  A61K9/10

CPC分类号： C07D471/08 ,  A61K49/085 ,  A61K49/10 ,  A61K49/106 ,  A61K49/1854 ,  C07F9/6561

摘要： The invention relates to chelate compounds that can be used in MRI, whereby said chelates are intended to be delivered by lipophilic carriers such as liposomes or lipidic nanoparticles. The invention also relates to compounds comprising a combination of said chelates and carriers which are connected, if necessary, by chemical linkage groups, and to the use thereof in diagnostic imaging, whereby said combination can also comprise biological target markers known as biovectors.

公开(公告)号：EP1469989A4

公开(公告)日：2006-07-05

申请号：EP03705645

申请日：2003-01-02

申请人： VISEN MEDICAL INC

发明人： GAW DEBRA A ,  JOSEPHSON LEE

IPC分类号： A61K9/50 ,  A61K47/48 ,  B32B5/16 ,  G01N33/15 ,  G01N33/543

CPC分类号： A61K49/1854 ,  A61K9/5026 ,  A61K9/5094 ,  B82Y5/00

公开(公告)号：EP0727224A2

公开(公告)日：1996-08-21

申请号：EP95118147.8

申请日：1991-03-30

申请人： NYCOMED IMAGING A/S

发明人： Klaveness, Jo ,  Ege, Thorfinn, c/o Nycomed Imaging AS ,  Rocklage, Scott M.

IPC分类号： A61K49/00

CPC分类号： A61K49/126 ,  A61K49/085 ,  A61K49/103 ,  A61K49/106 ,  A61K49/16 ,  A61K49/18 ,  A61K49/1812 ,  A61K49/1854 ,  A61K49/1863 ,  A61K49/1875 ,  A61K49/20 ,  Y10S436/806 ,  Y10S514/836 ,  Y10T436/24

摘要： The use of paramagnetic chelates as contrast agents in magnetometric analysis, especially imaging, and in particular structural and functional, diagnosis or imaging is described.

公开(公告)号：EP0523116B1

公开(公告)日：1996-06-19

申请号：EP91907007.8

申请日：1991-03-30

申请人： NYCOMED IMAGING AS

发明人： KLAVENESS, Jo ,  EGE, Thorfinn ,  ROCKLAGE, Scott, M.

IPC分类号： A61K49/00

CPC分类号： A61K49/126 ,  A61K49/085 ,  A61K49/103 ,  A61K49/106 ,  A61K49/16 ,  A61K49/18 ,  A61K49/1812 ,  A61K49/1854 ,  A61K49/1863 ,  A61K49/1875 ,  A61K49/20 ,  Y10S436/806 ,  Y10S514/836 ,  Y10T436/24

摘要： The use of superparamagnetic particles and of paramagnetic materials (such as lanthanide chelates) as contrast agents in magnetometric analysis, especially imaging, and in particular structural and functional, diagnosis or imaging is described.

公开(公告)号：EP0546939A1

公开(公告)日：1993-06-16

申请号：EP92403345.9

申请日：1992-12-09

申请人： MOLECULAR BIOQUEST, INC.

发明人： Chagnon, Mark S. ,  Ferris, John R. ,  Fiore, Barry L. ,  Carter, Michelle J. ,  Hamilton, Tracy J.

IPC分类号： A61K49/00 ,  A61K47/48

CPC分类号： A61K49/1821 ,  A61K47/6923 ,  A61K47/6941 ,  A61K49/183 ,  A61K49/1833 ,  A61K49/1854 ,  A61K49/1887 ,  Y10S428/90 ,  Y10T428/256 ,  Y10T428/26 ,  Y10T428/2989 ,  Y10T428/2998 ,  Y10T436/24

摘要： Subdomain metal or metal oxide particles covalently coupled to chemically reactive organic moieties and subsequently reacted together to form biodegradable magnetic microclusters are disclosed. The magnetic microcluster can be used as contrast agents in NMR imaging for the production of images suitable for use in diagnosis, for in vivo delivery and targeting of drugs, as in vivo , biodegradable agents for the sequestering of free metal ions in the treatment of metal driven disease.

摘要翻译： 公开了共价耦合到化学反应性有机部分并随后一起反应以形成可生物降解的磁性微团簇的子域金属或金属氧化物颗粒。 磁性微团簇可用作NMR成像中的造影剂，用于生产适合用于诊断，体内递送和靶向药物的图像，如体内，用于在金属处理中游离金属离子螯合的可生物降解剂 驱动疾病

公开(公告)号：EP2647391A4

公开(公告)日：2016-07-06

申请号：EP11845744

申请日：2011-09-29

申请人： KANEKA CORP

发明人： TAGO YOSHIYUKI ,  YOSHIDA SHINICHI ,  OHNO KOHJI ,  TSUJII YOSHINOBU ,  TABATA YASUHIKO

IPC分类号： A61K49/00 ,  A61K49/18

CPC分类号： A61K49/12 ,  A61K49/1854 ,  A61K49/186

摘要： Intended is to provide an MRI contrast agent that tends not to be phagocytized by reticuloendothelial cells and that has improved dispersion stability. The present invention is an MRI contrast agent containing composite particles, wherein the composite particles are those with polymer graft chains bound to surfaces of microparticles at a very high density sufficient to allow steric repulsion to occur between the graft chains, the microparticles are inorganic microparticles that exhibit superparamagnetism, and the polymer graft chains have a number average molecular weight (Mn) of at least 30,000. Preferably, the MRI contrast agent is for tumor diagnosis.