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1.发明公开COMPOSITION FOR INHIBITING CANCER METASTASIS CONTAINING DLK1-FC FUSION PROTEIN AS AN ACTIVE INGREDIENT 有权成分用于抑制癌细胞转移的DLK1-Fc融合蛋白AS主动 -
公开(公告)号：EP2548887A4
公开(公告)日：2013-12-04
申请号：EP10838389
申请日：2010-04-13
发明人： PARK YOUNG WOO , JO KIWON , LEE DONGHEE , YU JUNG , PARK JI HYUN , PARK CHAN-WOONG , KIM EUN JIN , PARK YUN JUNG
IPC分类号： C07K14/475
CPC分类号： C07K16/00 , C07K14/435 , C07K14/475 , C07K2319/30 , Y10S424/809 , Y10S530/866
摘要： A recombinant expression vector, comprising extracellular soluble domain genes of DLK1 and IgG antibody Fc domain genes, is constructed, and DLK1-Fc fusion protein is expressed and purified at 293E cell. The invention confirmed the efficacy as a drug for inhibiting cancer metastasis by confirming markedly reduced migration of cancer cells by DLK1-Fc fusion protein and also computing pharmacokinetic parameters. DLK1-Fc fusion protein has relatively higher stability than non-fusion protein, significantly reduces migration of various cancer cell lines, and provides superior cancer metastasis inhibition effect even at small concentration. Accordingly, DLK1-Fc fusion protein can be used efficaciously as an effective ingredient of a composition for inhibiting cancer metastasis.
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2.发明公开DUAL ANTAGONIST FOR TNF- AND IL-21 FOR PREVENTING AND TREATING AUTOIMMUNE DISEASES 有权对TNF-α和IL-21双重拮抗剂自身免疫性疾病的预防和治疗
公开(公告)号：EP2548893A4
公开(公告)日：2013-08-14
申请号：EP11756589
申请日：2011-03-18
申请人： KOREA RES INST OF BIOSCIENCE , INDUSTRY ACADEMIC COOPERATION FOUNDATION THE CATHOLIC UNIVERSITY OF KOREA
发明人： PARK YOUNG WOO , JO KI WON , YOO SROK HO , YU JUNG , YOON SUN-HA , PARK JI HYUN , SONG EUN JUNG , LEE JONG-HO , SEO MIN JI , CHO SUN JUNG , CHO MI LA , KIM HO YOUN , PARK MI KYUNG , OH HYE JWA , PARK JIN SIL , WOO YUN JU , BYUN JAE KYEONG , RYU JUN GEOL
IPC分类号： A61P37/00 , C07K14/715
CPC分类号： C07K14/7151 , C07K14/7155 , C07K2319/00
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公开(公告)号：EP2344533A4
公开(公告)日：2013-06-19
申请号：EP08877439
申请日：2008-11-10
发明人： PARK YOUNG WOO , CHOI SO-YOUNG , JANG YOUNG-SOON , PARK JI HYUN , SONG EUN-JUNG , YU JUNG , SOHN MYUNG-HO , JEON JAE WON , JUNG JOON-GOO , KIM SUNGSUB , JANG MYEOUNG HEE
IPC分类号： C07K16/18
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C12N9/6424
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公开(公告)号：EP2207803A4
公开(公告)日：2010-11-24
申请号：EP08871163
申请日：2008-11-24
发明人： PARK YOUNG WOO , CHOI SO-YOUNG , PARK JI HYUN , YU JUNG , SONG EUN-JUNG , KIM SUNGSUB , JANG MYEOUNG HEE , PARK MI-JU , LEE JE-HO , HWANG JAE RYOUNG
IPC分类号： C07K16/00 , A61K39/395 , A61P35/00 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2896 , C07K2317/21 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/76
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